1320340-86-0Relevant academic research and scientific papers
Antibacterial synergist, preparation method and uses thereof
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, (2018/03/28)
The present invention relates to an antibacterial synergist, a preparation method and uses thereof, and specifically discloses a compound represented by a formula (I) and having antibacterial synergyactivity, or an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The present invention further discloses a medical composition containing the compound, and uses thereof. According to the present invention, the compound can effectively enhance the antibacterial activity of polymyxin B against Acinetobacter baumannii and Klebsiella pneumoniae, and can be used for the antibacterial treatment of pathogenic bacteria insensitive to polymyxin or having low bacterial inhibition activity. The formula (I) is defined in the specification.
Eco-friendly synthesis of 2-aminothiazoles using Nafion-H as a recyclable catalyst in PEG-water solvent system
Kidwai, Mazaahir,Chauhan, Ritika,Bhatnagar, Divya
experimental part, p. 37 - 44 (2011/12/05)
A simple, efficient, single step and environmentally benign synthesis of 2-aminothiazoles is described in this paper. This green protocol was catalyzed by recyclable solid supported Nafion-H using polyethylene glycol-water solvent system with improved efficiency and reduced waste production.
Parallel solution-phase synthesis of a 2-aminothiazole library including fully automated work-Up
Buchstaller, Hans-Peter,Anlauf, Uwe
scheme or table, p. 104 - 108 (2012/04/18)
A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure. 2011 Bentham Science Publishers Ltd.
