1320346-45-9

Usage

Uses

Protected LY 338979 (L486650), a metabolite of the antifolate Pemetrexed (P219500).

Upstream product

• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 193265-47-3 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid 
• 1320346-43-7 methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate 
• 1320346-37-9 C₁₂H₁₂Br₂O₃ 

Downstream Products

• 193281-00-4 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid 

Relevant academic research and scientific papers

A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines

A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d] pyrimidines has been developed by the cyclocondensation of α,α- dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.