193281-00-4

Usage

Uses

LY 338979 is a metabolite of the antifolate Pemetrexed (P219500).

Upstream product

• 1320346-37-9 C₁₂H₁₂Br₂O₃ 
• 1320346-43-7 methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate 
• 193265-47-3 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid 
• 1320346-45-9 dimethyl 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 182009-04-7 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic acid 

Relevant academic research and scientific papers

Preparation method of related substance of pemetrexed and medicinal salts thereof

The invention discloses a preparation method of a related substance of pemetrexed and medicinal salts thereof. The structure of related substance of pemetrexed and medicinal salts thereof is shown asa formula (I). The related substance is prepared by one-step reaction of pemetrexed and an oxidizing agent under the action of a catalyst. The simple and convenient preparation method of related substance of pemetrexed and medicinal salts thereof is provided, and provides a new way for further identifying, separating, preparing and characterizing the oxidation related substance of pemetrexed and medicinal salts thereof and improving the quality control level and medication safety of pemetrexed and medicinal salts thereof.

A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines

A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d] pyrimidines has been developed by the cyclocondensation of α,α- dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.