132036-90-9

Basic information

• Product Name: ramosetron
• Synonyms: Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, (S)- (9CI)
• CAS NO: 132036-90-9
• Molecular Formula: C17H17N3O
• Molecular Weight: 279.34
• Mol File: 132036-90-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 579.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 14.57±0.40(Predicted)
• CAS DataBase Reference: ramosetron(CAS DataBase Reference)
• NIST Chemistry Reference: ramosetron(132036-90-9)
• EPA Substance Registry System: ramosetron(132036-90-9)

Safety Data

• Hazardous Substances Data: 132036-90-9(Hazardous Substances Data)

Upstream product

• 603-76-9 1-methylindole 
• 67-66-3 chloroform 

Downstream Products

• 137887-27-5 Ramosetron hydrochloride 

Relevant articles and documents

Synthesis method of Ramosetron

The invention discloses a synthesis method of Ramosetron. According to the method, 3,4-diaminobenzoic acid is used as a starting raw material for finally preparing the Ramosetron through the synthesis of benzimidazole-5-carboxylic acid, benzimidazole-5-methyl carbonate sulfate, 4,5,6,7-tetrahydro benzimidazole-5-methyl carbonate sulfate, 4,5,6,7-tetrahydro benzimidazole-5-triazolylformate sulfate, N-[(4,5,6,7-tetrahydro benzimidazole-5-yl)] pyrrole hydrochloride and 5-[(1-methylindol -3-yl) carbonyl]-4,5,6,7-tetrahydro benzimidazole. Compared with the prior art, the method provided by the invention has the advantages that the reaction conditions are optimized; after the optimization, the reaction is really feasible; the yield of the 4,5,6,7-tetrahydro benzimidazole-5-methyl carbonate sulfate, the 4,5,6,7-tetrahydro benzimidazole-5-triazolylformate sulfate, the N-[(4,5,6,7-tetrahydro benzimidazole-5-yl)] pyrrole hydrochloride and the like is improved; the reaction total yield reaches more than 30 percent; higher economic benefits are realized.