1320360-56-2

Basic information

• Product Name: 6,8-dibromo-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one
• Synonyms: 6,8-dibromo-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one
• CAS NO: 1320360-56-2
• Molecular Weight: 399.057
• Mol File: 1320360-56-2.mol

Chemical Properties

• CAS DataBase Reference: 6,8-dibromo-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-dibromo-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one(1320360-56-2)
• EPA Substance Registry System: 6,8-dibromo-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one(1320360-56-2)

Safety Data

• Hazardous Substances Data: 1320360-56-2(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 13445-89-1 1-(2-amino-3,5-dibromophenyl)ethanone 
• 551-93-9 2-aminoacetophenone 
• 155370-03-9 2-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-quinolone 

Downstream Products

• 1332337-60-6 2-(4-fluorophenyl)-6,8-diphenylquinolin-4(1H)-one 
• 1332337-64-0 2,6,8-tris(4-fluorophenyl)quinolin-4(1H)-one 
• 1332337-68-4 2-(4-fluorophenyl)-4-methoxy-6,8-diphenylquinoline 
• 1332337-72-0 2,6,8-tris(4-fluorophenyl)-4-methoxyquinoline 
• 1332337-56-0 2,6,8-tris(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one 
• 1332337-52-6 2-(4-fluorophenyl)-6,8-diphenyl-2,3-dihydroquinolin-4(1H)-one 
• 1421590-18-2 6,8-dibromo-2-(4-fluorophenyl)quinolin-4(1H)-one 
• 1421590-15-9 6,8-dibromo-2-(4-fluorophenyl)-4-methoxyquinoline 

Relevant articles and documents

Synthesis and photophysical properties of 2-Aryl-6,8-bis(arylethenyl)-4- methoxyquinolines

Iodine-methanol mediated oxidative-Aromatization of 2-Aryl-6,8-dibromo-2,3- dihydroquinolin-4(1H)-ones afforded the corresponding 2-Aryl-6,8-dibromo-4- methoxyquinolines in high yield and purity. The isomeric 1-(2-Amino-3,5- dibromophenyl)-3-Aryl-2- propen-1-ones reacted with iodine in methanol afford in a single pot operation the corresponding 2-Aryl-6,8-dibromo-4-methoxyquinoline (major) and 2-Aryl-6,8- dibromoquinolin-4(1H)-one (minor) products that were separated in sequence by column chromatography on silica gel. Suzuki-Miyaura cross-coupling of the 6,8-dibromo-4- methoxyquinoline derivatives with excess arylvinylboronic acids afforded the corresponding 2-Aryl-6,8-bis(2-Arylethenyl)- 4-methoxyquinolines. The absorption and fluorescence properties of these compounds were also determined.

Synthesis, evaluation of 6,8-dibromo-2-aryl-2,3-dihydroquinolin-4(1H)-ones in MCF-7 (breast cancer) cell lines and their docking studies

A series of novel 6,8-dibromo-2-aryl-2,3-dihydroquinolin-4(1H)-ones have been synthesized and evaluated in vitro (in MCF-7 breast cancer cell lines). Compounds 5a, 5d, 5e, and 5g exhibited potent GI50 and TGI values compared with reference stan

Suzuki-Miyaura cross-coupling of 2-aryl-6,8-dibromo-1,2,3,4- tetrahydroquinolin-4-ones and subsequent dehydrogenation and oxidative aromatization of the resulting 2,6,8-triaryl-1,2,3,4-tetrahydroquinolin-4-ones

Dichlorobis(triphenylphosphine)palladium(II)/tricyclohexylphosphine- catalyzed Suzuki-Miyaura cross-coupling of the 2-aryl-6,8-dibromo-1,2,3,4- tetrahydroquinolin-4-ones with arylboronic acids afforded the corresponding 2,6,8-triaryl-1,2,3,4-tetrahydroqui