13205-51-1Relevant academic research and scientific papers
Thioetherification via Photoredox/Nickel Dual Catalysis
Jouffroy, Matthieu,Kelly, Christopher B.,Molander, Gary A.
supporting information, p. 876 - 879 (2016/03/04)
Hypervalent alkylsilicates represent new and readily accessible precursors for the generation of alkyl radicals under photoredox conditions. Alkyl radicals generated from such silicates serve as effective hydrogen atom abstractors from thiols, furnishing thiyl radicals. The reactive sulfur species generated in this manner can be funneled into a nickel-mediated cross-coupling cycle employing aromatic bromides to furnish thioethers. The serendipitous discovery of this reaction and its utilization for the thioetherification of various aryl and heteroaryl bromides with a diverse array of thiols is described. The S-H selective H atom abstraction event enables a wide range of functional groups, including those bearing protic moieties, to be tolerated. (Chemical Equation Presented).
CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
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Page/Page column 157, (2012/09/10)
The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
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Paragraph 0383; 0384; 0385, (2013/03/26)
The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
A BIOMIMETIC SYNTHESIS OF CHRISANTEMOL
Babin, D.,Fourneron, J. D.,Harwood, L. M.,Julia, M.
, p. 325 - 332 (2007/10/02)
The factors governing the competition between 1,2- and 1,3-eliminations have been studied and the results obtained have been applied to a biomimetic synthesis of chrysantemol.
