13205-60-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanamine, N-ethyl-2-methylis used as an intermediate in the synthesis of various pharmaceuticals for its ability to react with other compounds to form new molecules with potential therapeutic effects.
Used in Water Treatment Industry:
1-Propanamine, N-ethyl-2-methylis used as a corrosion inhibitor in water treatment systems to prevent the degradation of metal surfaces and extend the life of equipment, ensuring the efficient operation of water systems.
Used in Cleaning Products Industry:
1-Propanamine, N-ethyl-2-methylis used as a surfactant in cleaning products to lower the surface tension of water, allowing it to mix with oil and dirt, making it easier to clean various surfaces.
Safety Precautions:
N-ethyl-2-methylpropan-1-amine is considered a flammable and hazardous substance. It is crucial to follow safety guidelines and regulations when handling and storing this chemical to prevent potential risks to human health and the environment.

Upstream product

• 56134-20-4 2-methyl-pentan-3-one oxime 
• 78-82-0 Isobutyronitrile 
• 75-04-7 ethylamine 

Downstream Products

• 64796-72-1 3-[1-(3-Chloro-phenyl)-1-methyl-ethyl]-1-ethyl-1-isobutyl-urea 
• 53516-47-5 Cyclohexen-1-yl-ethylisobutylamin 

Relevant academic research and scientific papers

An efficient synthesis of tertiary amines from nitriles in aprotic solvents

Tertiary amines are utilized extensively as non-nucleophilic proton scavengers for a number of organic transformations. Herein we report the efficient syntheses of tertiary alkyl amines from their corresponding alkyl nitriles in the presence of a heterogeneous palladium catalyst and a source of dihydrogen in aprotic solvents. The reaction is atom economic, the conditions are mild, and the isolated yields are virtually quantitative. The degree of amine alkylation shows some solvent dependency; in polar protic solvents such as ethanol or methanol, the reaction affords a mixture of products with the secondary alkyl amine as the major product.

Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring by reductive ring expansion using diisobutylaluminum hydride and studies on the reaction mechanism

(Chemical Equation Presented) A systematic investigation of the reductive ring-expansion reaction of cyclic ketoximes fused to aromatic ringswith diisobutylaluminum hydride (DIBALH) is described. This reaction regioselectively afforded a variety of five- to eight-membered bicyclic heterocycles or tricyclic heterocycles containing nitrogen neighboring an aromatic ring, including indoline, 1,2,3,4,5,6-hexahydrobenz[b]azocine, 3,4-dihydro-2H-benzo[b] [1,4]oxazine, 2,3,4,5-tetrahydrobenzo[b][1,4]thiazepine, 1,2,3,4,5,6- hexahydroazepino[3,2-b]-indole, 2,3,4,5-tetrahydro-1H-benzothieno[2,3-b]azepine, 2,3,4,5-tetrahydro-1H-benzothieno[3,2-b]-azepine, 5,6-dihydrophenanthridine, and 5,6,11,12-tetrahydrodibenz[b, f]azocine. The reaction mechanism leading to the rearrangement was investigated on the basis of the restricted Becke three-parameter plus Lee-Yang-Parr (B3LYP) density functional theory (DFT) with the 6-31G (d) basis set. It was found that the reaction proceeds through a three-centered transition state via a stepwise mechanism because the potential energy curve along the intrinsic reaction coordinate (IRC) had twomaxima (saddle points; TS1 and TS2) and the partial phenonium cation intermediate C. In addition to cyclic ketoximes fused to aromatic rings, the reactions of various cyclic and acyclic ketoximeswere examined to investigate preference of migrating group. It was found that themore electron-rich group migrated preferentially to give the corresponding secondary amines.