13206-67-2 Usage
Uses
Used in Oncology:
1-(2-chloroethyl)-1-nitroso-3-phenylurea is used as a chemotherapeutic agent for the treatment of various types of cancer. It is particularly effective in treating brain tumors due to its ability to cross the blood-brain barrier. 1-(2-chloroethyl)-1-nitroso-3-phenylurea works by interfering with the DNA replication process in cancer cells, leading to their death.
Used in the Treatment of Brain Tumors:
1-(2-chloroethyl)-1-nitroso-3-phenylurea is used as a first-line treatment for brain tumors, including malignant gliomas and other primary brain cancers. Its ability to cross the blood-brain barrier makes it a valuable option for patients with these aggressive and often difficult-to-treat tumors.
Used in the Treatment of Multiple Myeloma:
1-(2-chloroethyl)-1-nitroso-3-phenylurea is used as a chemotherapeutic agent for the treatment of multiple myeloma, a cancer of plasma cells. It is often used in combination with other drugs to increase the effectiveness of treatment and improve patient outcomes.
Used in the Treatment of Hodgkin's Lymphoma:
1-(2-chloroethyl)-1-nitroso-3-phenylurea is used as a component of multi-agent chemotherapy regimens for the treatment of Hodgkin's lymphoma, a type of cancer that affects the lymphatic system. Its alkylating properties make it a valuable addition to treatment plans for this aggressive cancer.
Common side effects of 1-(2-chloroethyl)-1-nitroso-3-phenylurea include bone marrow suppression, nausea, and vomiting. Due to its potent and potentially toxic nature, it should only be administered under the supervision of a qualified healthcare professional to ensure safe and effective treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 13206-67-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,0 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13206-67:
(7*1)+(6*3)+(5*2)+(4*0)+(3*6)+(2*6)+(1*7)=72
72 % 10 = 2
So 13206-67-2 is a valid CAS Registry Number.
13206-67-2Relevant academic research and scientific papers
The relationship between solvatochromic properties and in silico ADME parameters of new chloroethylnitrosourea derivatives with potential anticancer activity and their β-Cyclodextrin complexes
Fisli, Hassina,Hennig, Andreas,Chelaghmia, Mohamed Lyamine,Abdaoui, Mohamed
supporting information, (2021/02/27)
In view of the anticancer effect of nitrosoureas a set of four new N-(2-chloroethyl)-N-nitrosourea (CENU) derivatives was synthesized. An in silico absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) prediction study revealed that the
1,2,2,2-Tetrachloroethyl Carbamates: Versatile Intermediates for the Synthesis of N-Nitrosoureas
Barcelo, Gerard,Senet, Jean-Pierre,Sennyey, Gerard
, p. 1027 - 1029 (2007/10/02)
1,2,2,2-Tetrachloroethyl carbamates 3 were prepared by the reaction of 1,2,2,2-tetrachloroethyl carbonochloridate with amines.Carbamates 3 were then nitrosated and reacted with amines to yield N-nitrosoureas.
