132065-52-2Relevant academic research and scientific papers
A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-Vinylaziridines over Their 2,3-Trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosteres
Ibuka, Toshiro,Mimura, Norio,Aoyama, Hiroshi,Akaji, Masako,Ohno, Hiroaki,Miwa, Yoshihisa,Taga, Tooru,Nakai, Kazuo,Tamamura, Hirokazu,Fujii, Nobutaka,Yamamoto, Yoshinori
, p. 999 - 1015 (2007/10/03)
Palladium(0)-catalyzed reactions of N-methanesulfonyl- or N-(arenesulfonyl)-3-alkyl-2-vinylaziridines reveal that 2,3-cis-isomers are more stable than the corresponding 2,3-trans-isomers in accord with ab initio calculations. A highly stereoselective synthetic route to (E)-alkene dipeptide isosteres having desired stereochemistries from 2,3-cis-3-isobutyl-2-vinylaziridine by the use of organocopper chemistry is also presented.
New Synthetic Methodology for the Synthesis of 7-Substituted Tetrahydroazepin-2-ones
Evans, P. Andrew,Holmes, Andrew B.,Russell, Keith
, p. 3397 - 3410 (2007/10/02)
The Claisen rearrangement of the vinyl substituted ketene aminals 2 (R = CH2CHMe2, CH2OSit-BuMe2) which were generated in situ by selenoxide elimination of the aminal precursors 3 in the presence of 1,8-diazabicycloundec-7-ene (DBU) furnished the enantiomerically pure 7-substituted tetrahydroazepin-2-ones 1.
Synthesis Of Homochiral Unsaturated Seven-Membered Lactams
Evans, P. Andrew,Holmes, Andrew B.,Russell, Keith
, p. 593 - 596 (2007/10/02)
The Claisen rearrangement of the vinyl substituted ketene aminals 6 which were generated in situ by selenoxide elimination of the aminal precursors 5 in the presence of 1,8-diazabicycloundec-7-ene (DBU) gave the homochiral unsaturated seven-membere
