13208-27-0Relevant academic research and scientific papers
An easy access to unsymmetrical ureas: A photocatalytic approach to the Lossen rearrangement
Yadav, Arvind K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
, p. 24498 - 24503 (2014)
An efficient and operationally simple method for the synthesis of unsymmetrical ureas from various hydroxamic acids and amines has been developed. Plausibly, the protocol involves visible-light-initiated in situ formation of Vilsmeier-Haack reagent and COBr2 with CBr4 and a catalytic amount of DMF in the presence of Ru(bpy)3Cl2 as a photocatalyst to bring about the Lossen rearrangement at room temperature. the Partner Organisations 2014.
Pathways in the Degradation of Geminal Diazides
Holzschneider, Kristina,H?ring, Andreas P.,Haack, Alexander,Corey, Daniel J.,Benter, Thorsten,Kirsch, Stefan F.
, p. 8242 - 8250 (2017/08/14)
The degradation of geminal diazides is described. We show that diazido acetates are converted into tetrazoles through the treatment with bases. The reaction of dichloro ketones with azide anions provides acyl azides, through in situ formation of diazido ketones. We present experimental and theoretical evidence that both fragmentations may involve the generation of acyl cyanide intermediates. The controlled degradation of terminal alkynes into amides (by loss of one carbon) or ureas (by loss of two carbons) is also shown.
Iron(III) catalysed synthesis of unsymmetrical di and trisubstituted ureas - A variation of classical Ritter reaction
Basavaprabhu, Hosamani,Sureshbabu, Vommina V.
, p. 2528 - 2533 (2012/04/23)
An application of the classical Ritter reaction for the synthesis of unsymmetrical di and trisubstituted ureas catalyzed by FeCl3 is described. The protocol is of significant interest in view of the easy availability of precursors, mild reaction conditions employed and interestingly its applicability for the alkylation of alcohols capable of forming stable carbocationic intermediates even to the sterically hindered moieties. The Royal Society of Chemistry 2012.
PDE4 inhibitors: New xanthine analogues
Montana, John G.,Cooper, Nicola,Dyke, Hazel J.,Gowers, Lewis,Gregory, Joanna P.,Hellewell, Paul G.,Miotla, Jadwiga,Morris, Ken,Naylor, Robert,Tuladhar, Bishwa,Warneck, Julie B.H.
, p. 2925 - 2930 (2007/10/03)
Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.
