13208-36-1Relevant academic research and scientific papers
Copper(II) Complex of a Urea-functionalized Pyridyl Ligand: Synthesis, Crystal Structure, and Acetate Binding Properties
Yang, Zaiwen,Li, Chun,Liu, Xiangrong,Zhao, Shunsheng,Qu, Mengnan,Sun, Shasha,Zhang, Zhen,Yang, Zheng,Chen, Xinjuan
, p. 1324 - 1330 (2020)
A copper(II) acetate complex with a urea-functionalized pyridyl ligand, [CuL(OAc)2]2·2AcOH (1) [L = N-(3-chlorophenyl)-N'-(3-pyridyl) urea], was synthesized by the reaction of L with Cu(OAc)2 in methanol. A zigzag-shaped hydrogen bond chain of L is obtained via urea N–H···Npyridyl interactions, and a two-dimensional hydrogen bond network structure is further formed through the C–H···O interaction. In the complex 1, a paddle-wheel structure is generated by Cu···Oacetate interactions and Cu···Npyridyl interactions. Furthermore, hydrogen bonding chain structure is extended through weak C–H···O hydrogen bond interactions. Through ultraviolet-visible (UV/Vis) spectroscopy, the acetate binding properties of L in solution were also evaluated. Variable temperature magnetic susceptibility measurement indicates that the metal complex 1 displays antiferromagnetic coupling property.
USE OF PYRIDINE UREA COMPOUND HAVING SNAIL-KILLING ACTIVITY
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Paragraph 0068-0070; 0073, (2021/01/29)
The present invention relates to use of a pyridine urea compound having snail-killing activities, and relates to a method for preparing the pyridine urea compound. In particular, the present invention discloses a compound having the structure as shown in formula (I), an optical isomer thereof, a racemate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, the compound having a significant killing effect on various snails as parasitic disease vectors and low toxicity to non-target organism fish.
Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists
Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Davies, Susannah,Duckworth, D.Malcolm,Forbes, Ian T.,Gadre, Angela,Ham, Peter,Jones, Graham E.,King, Frank D.,Saunders, Damian V.,Thewlis, Kevin M.,Vyas, Deepa,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Riley, Graham J.,Wood, Martyn D.
, p. 2767 - 2773 (2007/10/03)
A model series of 5-HT(2C) antagonists have been prepared by rapid parallel synthesis. These N-substituted phenyl-N'-pyridin-3-yl ureas were found to have a range of 5-HT(2C) receptor affinities and selectivities over the closely related 5-HT(2A) receptor. Extrapolation of simple SAR, derived from this set of compounds, to the more active but synthetically more complex 1-(3-pyridyl-carbamoyl)indoline series allowed us to target optimal substitution patterns and identify potent and selective 5-HT(2C/2B) antagonists. Copyright (C) 1999 Elsevier Science Ltd.
