132113-53-2

Upstream product

• 884507-19-1 1‐methyl‐6‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1H‐indole 
• 67-56-1 methanol 
• 132113-52-1 3-(2-bromo-3,4,5-trimethoxy-phenyl)-propionic acid 

Downstream Products

• 132113-60-1 Acetic acid 6-[6-(3-hydroxy-pent-4-enyl)-2,3,4-trimethoxy-phenyl]-5-oxo-5,6-dihydro-2H-pyran-2-yl ester 
• 132113-59-8 Acetic acid 5-oxo-6-[2,3,4-trimethoxy-6-(3-oxo-propyl)-phenyl]-5,6-dihydro-2H-pyran-2-yl ester 
• 132113-57-6 2-[6-(2-[1,3]Dioxolan-2-yl-ethyl)-2,3,4-trimethoxy-phenyl]-6-hydroxy-6H-pyran-3-one 
• 132113-56-5 [6-(2-[1,3]Dioxolan-2-yl-ethyl)-2,3,4-trimethoxy-phenyl]-furan-2-yl-methanol 
• 132113-58-7 3-[2-(6-Hydroxy-3-oxo-3,6-dihydro-2H-pyran-2-yl)-3,4,5-trimethoxy-phenyl]-propionaldehyde 
• 132113-55-4 2-[2-(2-Bromo-3,4,5-trimethoxy-phenyl)-ethyl]-[1,3]dioxolane 
• 132113-54-3 3-(2-Bromo-3,4,5-trimethoxy-phenyl)-propionaldehyde 

Relevant academic research and scientific papers

Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties

Based on the natural antimitotic agent allocolchicine as a lead structure, a series of novel indole-based allocolchicine congeners was synthesized and assessed in vitro for their cytostatic properties. Several compounds exhibited potent anti-proliferative and apoptosis-inducing activity towards lymphoma cells along with low unspecific cytotoxicity. The observed activity is supposed to result from the inhibition of microtubule assembly, as indicated by the tubulin polymerisation assay.

CONSTRUCTION OF THE TRICYCLIC SKELETON OF COLCHICINE via 1,3-DIPOLAR CYCLOADDITION

An approach to the total synthesis of the natural product colchicine, 1, is presented.The synthesis of the ether-bridgehead cycloheptenone 11 is described, utilizing a 1,3-dipolar cycloaddition as the key reaction for the construction of the two fused sev