132152-82-0Relevant academic research and scientific papers
New route to 4-aminocyclopent-2-en-1-ols: Synthesis and enantioselective rearrangement of 4-amino-substituted cyclopentene oxides
Barrett, Stephen,O'Brien, Peter,Steffens, H.Christian,Towers, Timothy D,Voith, Matthias
, p. 9633 - 9640 (2007/10/03)
A new route for the asymmetric synthesis of 4-aminocyclopent-2-en-1-ols (90% ee) for carbocyclic nucleoside analogue synthesis is described. The approach involves the stereoselective preparation of cis 4-amino-substituted cyclopentene oxides and subsequent chiral base-mediated rearrangement to the corresponding allylic alcohols. Full details on the synthesis and stereoselectivity of epoxidation of 4-amino-substituted cyclopentenes are presented. (C) 2000 Elsevier Science Ltd.
(+/-)-Carbocyclic 5'-Nor-2'-deoxyguanosine and Related Purine Derivatives: Synthesis and Antiviral Properties
Patil, Sharadbala D.,Koga, Masakazu,Schneller, Stewart W.,Snoeck, Robert,Clercq, Erik De
, p. 2191 - 2195 (2007/10/02)
Beginning with 3-cyclopenten-1-ylamine hydrochloride, the 5'-nor derivatives of carbocyclic 2'-deoxyguanosine (2), 2'-deoxyadenosine (3),, and 2,6-diaminopurine 2'-deoxyribofuranoside (4) have been prepared.These compounds were evaluated for antiviral pot
The synthesis of two 2'-deoxy carbocyclic purine nucleosides lacking the 5'-methylene
Koga,Schneller
, p. 5861 - 5864 (2007/10/02)
The synthesis of the adenine derivative (±)-(1α,2β,4α)-4-(6-amino-9H-purin-9-yl)-1,2-cyclopentanediol (2) and its hypoxanthine analogue (3) as carbocyclic nucleosides lacking the 5'-methylene is described in 7 steps from 3-cyclopenten-1-ylamine hydrochlor
