132171-71-2

Upstream product

• 73594-96-4 5-Amino-4-cyano-1-(2,5-dichlorophenyl)pyrazole 
• 305-15-7 (2,5-dichlorophenyl)hydrazine 
• 132171-75-6 1-(2,5-Dichlorophenyl)-4,6-dihydroxypyrazolo<3,4-d>pyrimidine 
• 132171-76-7 1-(2,5-Dichlorophenyl)-4,6-dichloropyrazolo<3,4-d>pyrimidine 
• 132171-77-8 6-Chloro-1-(2,5-dichlorophenyl)-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine 
• 132171-74-5 5-Amino-4-carboxamide-1-(2,5-dichlorophenyl)pyrazole 
• 132171-78-9 Ethyl 6-chloro-1-(2,5-dichlorophenyl)-4,5-dihydro-1H-pyrazolo<3,4-d>pyrimidine-5-acetate 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Cyclic guanidines: Synthesis and antiplatelet activity of 4,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-7-ones and 1,4,6,7,8,9-hexahydropyrazolo [3',4':4,5]pyrimido[2,1-c][1,2,4]triazin-7-ones

A series of 4,6,7,8-tetrahydro-1H-imidazo[1,2-alpyrazolo[3,4-d]pyrimidin-7-ones (1b-n) and 1,4,6,7,8,9-hexahydropyrazolo[3',4':4,5]pyrimido[2,1-c][1,2,4]triazin- 7-ones has been synthesized. In view of their potential anti-aggregating activity the compounds were tested in vitro for inhibitory activity towards ADP- and collagen-induced aggregation of human platelets. Among the compounds studied, 8-benzyl-1-(2,5-dichlorophenyl)-4,6,7,8-tetrahydro-1H-imidazo[1,2-a]py razolo[3,4-d]pyrimidin-7-one exhibited the most favorable activity. The 2,5-dichlorophenyl side chain is an important lipophilic and/or steric pharmacophore.