305-15-7

Basic information

• Product Name: 2,5-DICHLOROPHENYLHYDRAZINE
• Synonyms: 2,5-DICHLOROPHENYLHYDRAZINE;1-(2,5-DICHLOROPHENYL)HYDRAZINE;(2,5-dichlorophenyl)-hydrazin;Hydrazine, (2,5-dichlorophenyl)-;2,5-DICHLOROPHENYLHYRAZINE;2,5-Dichlorophenylhydrazine,98%
• CAS NO: 305-15-7
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• EINECS: 206-163-6
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 305-15-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 102-103 °C(lit.)
• Boiling Point: 291.88°C (rough estimate)
• Flash Point: 115.1 °C
• Appearance: light brown powder
• Density: 1.4668 (rough estimate)
• Vapor Pressure: 0.00848mmHg at 25°C
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Keep Cold
• PKA: 4.32±0.10(Predicted)
• BRN: 743382
• CAS DataBase Reference: 2,5-DICHLOROPHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROPHENYLHYDRAZINE(305-15-7)
• EPA Substance Registry System: 2,5-DICHLOROPHENYLHYDRAZINE(305-15-7)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36
• Safety Statements: 26-36/37-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MV2100000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 305-15-7(Hazardous Substances Data)

Usage

Chemical Properties

light brown powder

Uses

2,5-Dichlorophenylhydrazine was used in the preparation of D-erythrose 2,5-dichlorophenylhydrazon.

InChI:InChI=1/C6H6Cl2N2/c7-4-1-2-5(8)6(3-4)10-9/h1-3,10H,9H2

Upstream product

• 893-39-0 2,5,2',5'-tetrachlorodiazoaminobenzene 
• 7647-01-0 hydrogenchloride 
• 120-28-5 2,5-dichlorophenyl-diazonium chloride 
• 95-82-9 2,5 dichloroaniline 

Downstream Products

• 120640-02-0 maleic acid mono-[N'-(2,5-dichloro-phenyl)-hydrazide] 
• 132857-52-4 (3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid-[N'-(2,5-dichloro-phenyl)-hydrazide] 
• 95-82-9 2,5 dichloroaniline 
• 106-46-7 para-dichlorobenzene 
• 4381-30-0 2-(2,5-dichlorophenyl)pyridine 
• 4467-14-5 4-(2,5-Dichloro-phenyl)-pyridine 
• 73594-96-4 5-Amino-4-cyano-1-(2,5-dichlorophenyl)pyrazole 
• 672310-73-5 5,8-dichloro-2,3,4,9-tetrahydro-1H-carbazole 
• 202270-79-9 (η(5)-C5H5)Fe(η(5)-C5H4C(Me)=NNHC6H3-2,5-Cl2) 
• 1044590-53-5 C₁₆H₁₁Cl₂N₃O 
• 945487-69-4 N'-(2,5-dichlorophenyl)-5-bromofuran-2-carbohydrazide 
• 1201890-94-9 N-(tert-butoxycarbonyl)-L-valine 2,5-dichlorophenylhydrazide 
• 1201890-92-7 N-(tert-butoxycarbonyl)-L-alanine 2,5-dichlorophenylhydrazide 
• 190910-30-6 2,3,6-tri-O-benzyl4-deoxy-D-xylo-hexose (2,5-dichlorophenyl)hydrazone 

Relevant articles and documents

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Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Process for producing 3-anilino-5-pyrazolones

A process for producing a 3-anilino-5-pyrazolone which comprises reacting a β-anilino-β-alkoxy-acrylate with a hydrazine in the presence of a compound having a pKa of about 8 up to about 14.