13221-94-8

Usage

Synthesis Reference(s)

Tetrahedron, 35, p. 425, 1979 DOI: 10.1016/0040-4020(79)80083-6Tetrahedron Letters, 7, p. 3599, 1966

InChI:InChI=1/C9H16O2/c1-6(10)8(7(2)11)9(3,4)5/h8H,1-5H3

Upstream product

• 507-19-7 t-butyl bromide 
• 558-17-8 tert-Butyl iodide 
• 123-54-6 acetylacetone 
• 54008-24-1 (RS)-3-((SR)-1-hydroxy-ethyl)-4,4-dimethyl-pentan-2-one 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 28991-95-9 ethyl 4-tert-butyl-3,5-dimethyl-1H-pyrrole-2-carboxylate 
• 173972-05-9 benzyl 4-tert-butyl-3,5-dimethyl-1H-pyrrole-2-carboxylate 
• 173972-07-1 benzyl 5-acetoxymethyl-4-tert-butyl-3-methyl-1H-pyrrole-2-carboxylate 
• 544434-53-9 2,5-bis(5-benzyloxycarbonyl-3-tert-butyl-4-methyl-2-pyrrolylmethyl)-3,4-diethyl-1H-pyrrole 

Relevant academic research and scientific papers

Cerium-catalyzed α-hydroxylation reactions of α-cyclopropyl β-dicarbonyl compounds with molecular oxygen

Three α-cyclopropyl β-dicarbonyl compounds have been used as probes for α-radicals as electrophilic reaction intermediates in a cerium-catalyzed α-hydroxylation reaction with molecular oxygen. Since the cyclopropyl group did not ring-open to products with a butenyl moiety, but was retained in the products, a localized unpaired electron at the α position can be excluded during the course of the reaction. The α-cyclopropyl- substituted substrates were prepared by aldol or Claisen reactions. Other substrates with α-methyl, α-isopropyl, and α-tert-butyl substituents were prepared and converted under the α-hydroxylation conditions in order to estimate steric influences on the yield of the reaction. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

tert-butyl-substituted tripyrranes: Insights into the steric and conformational factors that influence porphyrinoid ring formation in the "3 + 1" methodology

The MacDonald "3 + 1" route for porphyrinoid synthesis involves the acid-catalyzed condensation of tripyrranes with monocyclic dialdehydes, followed by an oxidation step. In the present study, yields were found to be greatly diminished when tert-butyl sub

PREPARATION AND CONFORMATIONAL ANALYSIS OF SEVERELY HINDERED β-DIKETONES. DIPOLE MOMENT DETERMINATIONS AND THEORETICAL CALCULATIONS.

Several β-diketones bearing bulky substituents at the intercarbonyl positions have been prepared by alkylation of the cobalt(II) complexes of the unsubstituted diketones.Agreement between experimental and calculated dipole moments is fairly good thus rend

1-(2,2-Dimethylpropyl)-3,5-dimethylbenzene, an Unexpected Side Product

The title compound 4 is formed in fair yield in addition to the oligomers of isobutene during synthesis of 3-tert-butyl-2,4-pentanedione (2) from 2,4-pentanedione (1) with tert-butylalcohol and perchloric acid in nitromethane.Acid-catalyzed condensation of 1 with isooctene 5 is discovered to be responsible for the formation of 4.This reaction yields other meta-neopentyl-substituted benzene derivatives (19,20,21) with several β-diketones.