132219-93-3Relevant academic research and scientific papers
A study on the synthesis and properties of substituted EHBG-Fe(III) complexes as potential MRI contrast agents
Ku?nik, Nikodem,Szafraniec-Gorol, Grazyna,Oczek, Lidia,Grucela, Artur,Jewu?a, Pawe?,Ku?nik, Anna,Zassowski, Pawel,Domagala, Wojciech
, p. 100 - 105 (2014)
Mono- and disubstituted EHBG (HBED) ligands of different kind: forming hydrogen bonds (p-OMe, p-NHAc) and of high lipophilicity (3,4-Me2, p-Ph) were obtained. The ligands were complexed with Fe(III). Complexes so obtained were studied for their stability in different pH environments; and r1 relaxivity, which turned out the highest for Fe-EHBG-NHAc, i.e. 0.95 mM-1 s-1 in aqueous solution and 1.34 mM-1 s-1 for Fe-EHBG-Me2 in bovine serum. EPR signals were observed at g-factor of 4.27 indicative of Kramer's doublet transitions of a rhombically distorted high-spin paramagnetic center.
Complexes possessing ortho ligating functionality
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, (2008/06/13)
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The chelants possess the general formula STR1 wherein R'1, R'2, R'3, R'4, R'5 and R'6, Z' and X are all defined in the specification. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
