132235-43-9

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-Methyl-2-PyrrolidinecarboxaMide is used as a chiral building block for the production of various medications, particularly for the development of drugs with potential biological activity. Its unique structure allows for the creation of enantiomerically pure compounds, which is crucial for the efficacy and safety of pharmaceuticals.
Used in Organic Synthesis:
(2S)-2-Methyl-2-PyrrolidinecarboxaMide is used as a key intermediate in the synthesis of complex organic molecules, enabling the construction of chiral centers and the formation of specific stereoisomers. This is essential for the development of enantiomerically pure compounds with desired biological properties.
Used in Materials Science:
(2S)-2-Methyl-2-PyrrolidinecarboxaMide has been studied for its potential applications in materials science, where its unique structure and properties can contribute to the development of new materials with specific characteristics, such as chiral polymers or self-assembling systems.
Used in Catalysis:
(2S)-2-Methyl-2-PyrrolidinecarboxaMide has also been explored for its potential use in catalysis, where its chiral nature can be employed to promote enantioselective reactions, leading to the production of enantiomerically pure products with high yields and selectivity.

Upstream product

• 132235-40-6 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidine carboxamide 
• 132235-36-0 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-pyrrolidinecarbonitrile 
• 1415303-32-0 (2S,1'S)-N-(1'-phenylethyl)-α-methylprolinamide (S)-mandelic acid salt 
• 5891-21-4 5-chloro-2-pentanone 
• 42457-13-6 2-cyano-2-methylpyrrolidine 
• 1361112-89-1 2-methylpyrrolidine-2-carboxamide hydrochloride 
• 848488-83-5 DL-(α-methyl)proline amide 
• 1163706-66-8 (S)-2-methyl-pyrrolidine-2-carboxylic acid butyl ester 
• 63399-73-5 α-methyl-L-proline hydrobromide 
• 63399-71-3 (S)-1-((benzyloxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid 
• 6931-10-8 3,4-dihydro-5-methyl-2H-pyrrole 1-oxide 
• 1031890-09-1 benzyl (S)-2-carbamoyl-2-methylpyrrolidine-1-carboxylate 

Downstream Products

• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 
• 1163705-29-0 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(2,6-dichloro-benzyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide) 
• 1163705-28-9 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(2-fluoro-phenyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide) 
• 1163705-24-5 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[5-(2-benzyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-amide} 
• 1163705-34-7 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[5-(3-tert-butyl-phenyl)-4-methyl-thiazol-2-yl]-amide} 
• 1163705-64-3 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-[(5-{2-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl]-pyrimidin-4-yl}-4-methyl-thiazol-2-yl)-amide] 
• 1163705-69-8 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(1-phenyl-cyclopentyl)-pyrimidin-4-yl]-thiazol-2-yl}-amide) 
• 1163705-70-1 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(1,1-dimethyl-2-p-tolyl-ethyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide) 
• 1163705-63-2 (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({5-[2-(4-methoxy-phenoxymethyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-amide) 

Relevant academic research and scientific papers

Α-substd. provitamin optically active production of phosphorus

PROBLEM TO BE SOLVED: To provide an industrial method practically suitable for producing an optically active α-substituted prolines with short process and mild conditions.SOLUTION: A method of producing an optically active α-substituted prolines (6) includes (d) a step of obtaining an optically active N, α-substituted prolines (5) by hydrolysis of an optically active N, α-substituted proline amides (4), and (e) a step of obtaining an optically active α-substituted prolines (6) by eliminating the optically active N, and a protective group Rof the α-substituted prolines (5).

METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-SUBSTITUTED PROLINE

The present invention aims to provide an industrial method practically suitable for producing optically active α-substituted prolines from an acyclic ketone compound by a small number of steps under mild conditions. The present invention relates to a production method of an optically active α-substituted proline (4) and/or an optically active α-substituted prolinamide (5), including (a) reacting an acyclic ketone compound (1) with at least one selected from ammonia, an ammonium salt, primary amine and a salt of primary amine, and a cyanating agent to give a cyclic nitrogen-containing compound (2), (b) hydrating the cyclic nitrogen-containing compound (2) to give an α-substituted prolinamide (3), and (c) resolving the α-substituted prolinamide (3) by one or more of (d) enzymatical hydrolysis, (e) resolution by diastereomeric salt formation, and (f) separation by column chromatography.

2-Carboxamide Cycloamino Ureas

The present invention relates to compounds of formula I and salts thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol

Organic Compounds

The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

ORGANIC COMPOUNDS

The resent invention relates to a com ound of formula (I) and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-

Is the backbone conformation of Cα-methyl proline restricted to a single region?

Cα-Methyl-L-proline, or L(αMe)Pro, is probably the most conformational constrained α-amino acid. In particular, its ω and o torsion angles are restricted to about 180 and -60°, respectively, and only three ranges of values are theoretically ava

Preparation and Use of Chloromethyl (-)-Menthyl Ether in the Synthesis of Optically Pure α-Branched α-Amino Nitriles

The synthesis of optically pure chloromethyl (-)-menthyl ether (2b) and its use in the synthesis of di-(-)-menthyl acetal (-)-menthyl (+)-menthyl acetals are described.The diastereomeric mixed acetals 7a,b and 8a,b are easily obtainable from the nitrones 5 and 6, KCN and 2b.The mixture of diastereomers are separated into the pure components 7a, 7b and 8a, 8b by simple silica gel column chromatography.Hydrolysis of these products (H2O2/Na2CO3, ultrasound) followed by N-O cleavage affords the heterocyclic α-methyl-α-amino amides 11a, 11b and 12a, 12b.These are subsequently hydrolyzed to give the corresponding α-methyl-α-amino acids with S and R configuration, respectively.