63399-71-3

Basic information

• Product Name: 1-[(Benzyloxy)carbonyl]-2-methyl-L-proline
• Synonyms: 1-[(Benzyloxy)carbonyl]-2-methyl-L-proline;1-Cbz-2-methyl-L-proline
• CAS NO: 63399-71-3
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.28908
• Mol File: 63399-71-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(Benzyloxy)carbonyl]-2-methyl-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(Benzyloxy)carbonyl]-2-methyl-L-proline(63399-71-3)
• EPA Substance Registry System: 1-[(Benzyloxy)carbonyl]-2-methyl-L-proline(63399-71-3)

Safety Data

• Hazardous Substances Data: 63399-71-3(Hazardous Substances Data)

Usage

General Description

1-[(Benzyloxy)carbonyl]-2-methyl-L-proline is a chemical compound composed of a proline molecule with an additional benzyloxy carbonyl group and a methyl group attached to the alpha carbon. It is commonly used in organic synthesis and as a building block in pharmaceutical research and development. The benzyloxy carbonyl group serves as a protecting group for the proline molecule, allowing for selective manipulation of the molecule during chemical reactions. The methyl group on the proline molecule may influence its conformation and properties, making it useful in the development of new drugs and bioactive compounds. This chemical has potential applications in drug discovery and development processes.

Upstream product

• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 63399-73-5 α-methyl-L-proline hydrobromide 

Downstream Products

• 1013038-59-9 Z-L-α-MePro-L-Ala-OMe 
• 1175526-90-5 (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate 
• 1037254-18-4 benzyl (2S)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate 
• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 
• 132235-43-9 (S)-2-methylpyrrolidine-2-carboxylic acid amide 
• 1031890-09-1 benzyl (S)-2-carbamoyl-2-methylpyrrolidine-1-carboxylate 

Relevant articles and documents

Azetidine-derived amino acids versus proline derivatives. Alternative trends in reverse turn induction

(Figure Presented) The influence of 2-alkyl-2-carboxyazetidines (Aze) on the 3D structure of model tetrapeptides R2CO-2-R1Aze-L- Ala-NHMe has been analyzed by molecular modeling, 1H NMR, and FT-IR studies. The conformation

Preparation and Use of Chloromethyl (-)-Menthyl Ether in the Synthesis of Optically Pure α-Branched α-Amino Nitriles

The synthesis of optically pure chloromethyl (-)-menthyl ether (2b) and its use in the synthesis of di-(-)-menthyl acetal (-)-menthyl (+)-menthyl acetals are described.The diastereomeric mixed acetals 7a,b and 8a,b are easily obtainable from the nitrones 5 and 6, KCN and 2b.The mixture of diastereomers are separated into the pure components 7a, 7b and 8a, 8b by simple silica gel column chromatography.Hydrolysis of these products (H2O2/Na2CO3, ultrasound) followed by N-O cleavage affords the heterocyclic α-methyl-α-amino amides 11a, 11b and 12a, 12b.These are subsequently hydrolyzed to give the corresponding α-methyl-α-amino acids with S and R configuration, respectively.