132248-58-9 Usage
Uses
Used in NMR Spectroscopy:
2,2,2-Trifluoroethanol-1,1-d2 is used as a solvent in NMR spectroscopy for enhancing the resolution of spectral data. The incorporation of deuterium isotopes in the molecule allows for clearer identification and analysis of chemical structures and interactions within the sample being studied.
Used in Chemical Research:
In the field of chemical research, 2,2,2-Trifluoroethanol-1,1-d2 is utilized as a reagent or solvent to facilitate specific reactions or to study the properties of various compounds. Its unique characteristics, including its deuterated nature, make it a valuable tool for probing molecular interactions and understanding reaction mechanisms.
Used in Pharmaceutical Development:
2,2,2-Trifluoroethanol-1,1-d2 can be employed in the pharmaceutical industry for the development of new drugs and the study of drug candidates. Its use in NMR spectroscopy aids in the detailed analysis of drug molecules, which is crucial for optimizing their efficacy and safety.
Used in Material Science:
In material science, 2,2,2-Trifluoroethanol-1,1-d2 may be used to study the properties of new materials or to assist in the synthesis of advanced materials with specific characteristics. Its application in NMR spectroscopy provides insights into the molecular structure and dynamics of these materials, which can be critical for their development and application.
Check Digit Verification of cas no
The CAS Registry Mumber 132248-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,2,4 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 132248-58:
(8*1)+(7*3)+(6*2)+(5*2)+(4*4)+(3*8)+(2*5)+(1*8)=109
109 % 10 = 9
So 132248-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C2H3F3O/c3-2(4,5)1-6/h6H,1H2/i1D2
132248-58-9Relevant academic research and scientific papers
Reversible and Irreversible ElcB Mechanisms in the Hydrolysis of 2,2,2-Trifluoroethanesulfonyl Chloride: Carbanion Intermediates in Aqueous Acid
King, James F.,Gill, Manjinder Singh
, p. 808 - 811 (2007/10/03)
Hydrolysis of 2,2,2-trifluoroethanesulfonyl chloride (1) is shown to take place by way of the sulfene (CF3CH=SO2), formed by (a) an irreversible E1cB process over the pH range 1.8-5 with water acting as the carbanion-forming base in the lower pH range and hydroxide anion at higher pH, and (b) a reversible E1cB reaction in dilute acid.
Evidence for a concerted mechanism in the solvolysis of phenyldimethylsilyl ethers
Xu, Yiying,Dietze, Paul E.
, p. 10722 - 10727 (2007/10/02)
The trifluoroethoxide-catalyzed trifluoroethanolysis and the hydroxide-catalyzed hydrolysis of a series of phenyldimethylsilyl ethers were examined. A Bronsted plot of the logarithm of the second-order rate constant KTFE for reaction with trifluoroethanol against the pKLG is not linear. The nonlinear plot might be taken as evidence for a change in rate-determining step of a reaction that proceeds through a pentavalent intermediate. However, the Bronsted plot for the hydroxide-catalyzed hydrolysis, where all the leaving groups are of lower pKa than hydroxide, has an identical shape as the Bronsted plot for the trifluoroethanolysis reaction. Therefore, the unusual shape of the Bronsted plots is not due to a change in rate-determining step. It is suggested that the results are most consistent with a one-step concerted mechanism and not with a mechanism involving a pentavalent intermediate.
