132248-94-3Relevant academic research and scientific papers
Novel α-iodination of functionalized ketones with iodine mediated by bis(tetra-n-butylammonium) peroxydisulfate
Whang, Je Pil,Yang, Seung Gak,Kim, Yong Hae
, p. 1355 - 1356 (1997)
α,β-Unsaturated ketones, β-keto esters and uracil derivatives react with iodine in the presence of bis(tetra-n-butylammonium) peroxydisulfate under mild conditions in MeCN at 25°C to give the corresponding α-iodinated products in good yields.
Synthesis of α,β-unsaturated α′-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides
Pace, Vittorio,Castoldi, Laura,Holzer, Wolfgang
, p. 7764 - 7770 (2013/09/02)
A straightforward synthesis of variously functionalized α,β-unsaturated α′-haloketones has been achieved through the chemoselective addition of halomethyllithium carbenoids to Weinreb amides at -78 C. A comparative study employing the corresponding esters under the same reaction conditions pointed out that the instability of the tetrahedral intermediate formed from the latter is responsible for the observed formation of carbinols instead of the desired haloketones.
I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea
Zhu, Yan-Ping,Yuan, Jing-Jing,Zhao, Qin,Lian, Mi,Gao, Qing-He,Liu, Mei-Cai,Yang, Yan,Wu, An-Xin
supporting information; experimental part, p. 173 - 178 (2012/01/05)
A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis.
An efficient method for the selective iodination of ?±,?2- unsaturated ketones
Wang, Zihua,Yin, Guodong,Qin, Jing,Gao, Meng,Cao, Liping,Wu, Anxin
experimental part, p. 3675 - 3681 (2009/06/18)
An efficient approach to ?±,?2-unsaturated ?±'-iodo ketones directly from ?±,?2-unsaturated ketones by selective iodination at the ?±'-position, without effect on the double bond and the activated benzene ring, in the presence of copper (II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products. ? Georg Thieme Verlag Stuttgart ?· New York.
