13225-60-0

Upstream product

• 3355-31-5 1-chloro-3-phenyl-2-propyne 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 

Downstream Products

• 175439-15-3 bis-γ-phenylpropargyl sulfone 
• 93-55-0 1-phenyl-propan-1-one 
• 56146-95-3 4-phenyl-4,9-dihydro-naphtho[2,3-c]thiophene 
• 269717-71-7 bis-γ-phenylpropargyl sulfoxide 
• 27370-85-0 cis-1,6-diphenyl-3-hexene-1,5-diyne 
• 13305-02-7 trans-1,6-Bis(phenyl)hexa-1,5-diyn-3-ene 
• 24431-37-6 1,2,3-Trijod-1-phenyl-Δ¹-propen 

Relevant academic research and scientific papers

Direct conversion of dipropargylic sulfones into (E)- and (Z)-Hex-3-ene-1,5-diynes by a modified one-flask Ramberg-Backlund reaction

(E)- and (Z)-enediynes 7 are readily synthesized in good yields from a one-pot modified Ramberg-Backlund reaction from dipropargylic sulfones 5.

A direct route to conjugated enediynes from dipropargylic sulfones by a modified one-flask Ramberg-Baecklund reaction

The reaction of dipropargylic sulfones with dibromodifluoromethane in the presence of alumina-supported KOH in dichloromethane solution results in facile rearrangement affording the corresponding conjugated linear and cyclic enediynes in good yields. This result shows that the direct transformation of a- and a′-hydrogen bearing sulfones assembles enediyne units without resorting to the prior preparation of the a-halo sulfone precursors in a separate step.