1322592-07-3Relevant academic research and scientific papers
Highly enantio- and diastereoselective synthesis of β-methyl-γ- monofluoromethyl-substituted alcohols
Yang, Wenguo,Wei, Xinle,Pan, Yuanhang,Lee, Richmond,Zhu, Bo,Liu, Hongjun,Yan, Lin,Huang, Kuo-Wei,Jiang, Zhiyong,Tan, Choon-Hong
, p. 8066 - 8070 (2011)
Enanatiopure β-methyl-γ-monofluoromethyl alcohols were prepared from the allylic alkylation between fluorobis(phenylsulfonyl)methane with Morita-Baylis-Hillman carbonates. The reaction was catalyzed by using the Cinchona alkaloid derivative, (DHQD)2AQN. The origin of the stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed stereoselectivity.
