1322596-77-9

Basic information

• Product Name: 5-(dimethylamino)-2-(1-hydroxy-2,2-dimethylpropyl)phenol
• CAS NO: 1322596-77-9
• Molecular Weight: 223.315
• Mol File: 1322596-77-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(dimethylamino)-2-(1-hydroxy-2,2-dimethylpropyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(dimethylamino)-2-(1-hydroxy-2,2-dimethylpropyl)phenol(1322596-77-9)
• EPA Substance Registry System: 5-(dimethylamino)-2-(1-hydroxy-2,2-dimethylpropyl)phenol(1322596-77-9)

Safety Data

• Hazardous Substances Data: 1322596-77-9(Hazardous Substances Data)

Upstream product

• 41602-56-6 4-dimethylamino-2-hydroxy-benzaldehyde 
• 594-19-4 tert.-butyl lithium 

Relevant articles and documents

Enantioselective Br?nsted acid catalysis in the friedel-crafts reaction of indoles with secondary ortho -hydroxybenzylic alcohols

The reaction of indole and various methyl-substituted indoles with the title compounds was studied in the presence of chiral phosphoric acids, which act as Br?nsted acid catalysts. While yields were generally high (>90%), significant enantioselectivities (up to 77% ee) were only achieved for certain substrate-catalyst combinations. In addition, a kinetic resolution of the starting material was observed, which led to an enrichment of one chiral alcohol to up to 68% ee after 76% conversion. The Friedel-Crafts reaction is not stereospecific (no direct S-type substitution), but rather is likely to proceed via a cation, which is bound to the chiral Br?nsted acid or its anion in a close contact ion pair. Georg Thieme Verlag Stuttgart - New York.