41602-56-6Relevant academic research and scientific papers
Turn on ESPT: Novel salicylaldehyde based sensor for biological important fluoride sensing
Liu, Kai,Zhao, Xiaojun,Liu, Qingxiang,Huo, Jianzhong,Fu, Huifang,Wang, Ying
, p. 75 - 79 (2014)
A novel and simple salicylaldehyde based anion fluorescent sensor 1 has been designed, which can selectively sense fluoride by 'turn on' excited-state intermolecular proton transfer (ESPT). The binding constant and the stoichiometry were obtained by non-linear least-square analysis of the titration curves.
Temperature insensitive fluorescence intensity in a coumarin monomer-aggregate coupled system
Liu, Xiaogang,Mao, Deqi,Cole, Jacqueline M.,Xu, Zhaochao
, p. 9329 - 9332 (2014)
The emission intensities of a fluorescent monomer-aggregate coupled system, based on 7-(dimethylamino)-coumarin-3-carbaldehyde, exhibit ultra-low temperature dependence with a low temperature coefficient of only 0.05% per °C, by judicious selection of the excitation wavelength. This finding has significant implications to temperature-sensitive fluorescent applications.
Anagostic interactions in chiral separation. Polymorphism in a [Co(II)(L)] complex: Crystallographic and theoretical studies
Awwadi, Firas F.,Hodali, Hamdallah A.
, p. 373 - 381 (2018)
Syntheses and crystal structures of two polymorphs of the complex [Co(II)(L)], where H2L = 2,2’-[cis-1,2-diaminocyclohexanediylbis (nitrilo-methylidyne)]bis (5-dimethyl-amino]phenol, have been studied. The two polymorphs concomitantly crystallized by vapour diffusion of solvent. The first polymorph (I) crystallized as a racemate in the centrosymmetric tetragonal I41/a space group. The second polymorph (II) crystallized in the chiral orthorhombic space group P212121. The chiral conformers of symmetrical cis-1,2-disubstituted cyclohexane molecules cannot be resolved in the liquid or gas phases, due to the rapid ring inversion. In the present study, the two chiral conformers are present in crystals of polymorph I, whereas, only one chiral conformer is present in crystals of polymorph II. Crystal structure analysis indicated that the formation of two different polymorphs of [Co(II)(L)] complex can be rationalized based on C–H?Co anagostic interactions. Density Functional Theory (DFT) calculations indicated that C–H?Co interactions are due to HOMO-LUMO interactions.
Synthesis and study of novel coumarin derivatives potentially utilizable as memory media
Flasik, Radoslav,Stankovicova, Henrieta,Gaplovsky, Anton,Donovalova, Jana
, p. 4838 - 4848 (2009)
Novel coumarin derivatives, 2-oxo-2H-chromenecarbaldehyde hydrazones were prepared by reaction of substituted 2-oxo-2H-chromenecarbaldehydes with N-aminoimides in ethanol in the presence of 4-toluenesulfonic acid as catalyst. The photochromic and thermochromic properties of the prepared compounds were investigated.
Imidazolyl–benzocoumarins as ratiometric fluorescence probes for biologically extreme acidity
Kim, Hyerim,Sarkar, Sourav,Nandy, Madhurima,Ahn, Kyo Han
, (2021)
A rational approach to develop a fluorescent probe for sensing biologically “extreme” acidity (pH a = 1.3 among ratiometric probes known so far, which is ascribed due to a unique sensing mechanism. The probe has high quantum yields, high chemical stability and good aqueous solubility. The probe was successfully applied to ratiometric fluorescence imaging of intrabacterial acidity from pH 4.0–1.0, offering a practical means for studying biological systems under the extreme pH conditions.
Synthesis of N,N-Dialkylamino-nor-Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores and Their First Water-Soluble and/or Bioconjugatable Analogues
Ong, Michelle Jui Hsien,Debieu, Sylvain,Moreau, Mathieu,Romieu, Anthony,Richard, Jean-Alexandre
, p. 936 - 946 (2017)
The effective synthesis of extended conjugated N,N-dialkylamino-nor-dihydroxanthene-based fluorophores is described from diversely functionalized salicylic aldehydes. The access to these original fluorescent derivatives proceeded in two steps through a one-pot construction of the unusual nor-dihydroxanthene (nor-DHX) scaffold followed by a diversification step providing a wide variety of nor-DHX-hemicyanine fused dyes emitting in the range of 730–790 nm. The versatility of our approach has enabled a further extension to the late-stage introduction of negatively/positively charged polar groups onto their terminal nitrogen heterocyclic subunit, thereby giving access to the first water-soluble and/or bioconjugatable members of this emerging class of NIR fluorophores. Our water-solubilizing method is easily implementable, and the nor-DHX-hemicyanine skeleton maintains satisfying fluorescence quantum yields (5–20 %) under physiological conditions. Finally, the bioconjugation ability of fluorescent derivatives bearing a free carboxylic acid was demonstrated through the covalent labeling of a model protein, namely, bovine serum albumin.
Fluoride-driven 'turn on' ESPT in the binding with a novel benzimidazole-based sensor
Liu, Kai,Zhao, Xiaojun,Liu, Qingxiang,Huo, Jianzhong,Zhu, Bolin,Diao, Shihua
, p. 563 - 567 (2015)
A novel fluorescence sensor (BIP) bearing NH and OH subunits displayed a highly selective and sensitive recognition property for fluoride over other anions. Fluoride-driven ESPT, poorly used in anion recognition and sensing, was suggested to be responsible for the fluorescence enhancement with a blue shift of 35 nm in the emission spectrum.
A Color-Shifting Near-Infrared Fluorescent Aptamer–Fluorophore Module for Live-Cell RNA Imaging
J?schke, Andres,Sunbul, Murat,Wang, Lu,Zhang, Jingye
supporting information, p. 21441 - 21448 (2021/08/23)
Fluorescent light-up RNA aptamers (FLAPs) have become promising tools for visualizing RNAs in living cells. Specific binding of FLAPs to their non-fluorescent cognate ligands results in a dramatic fluorescence increase, thereby allowing RNA imaging. Here, we present a color-shifting aptamer-fluorophore system, where the free dye is cyan fluorescent and the aptamer-dye complex is near-infrared (NIR) fluorescent. Unlike other reported FLAPs, this system enables ratiometric RNA imaging. To design the color-shifting system, we synthesized a series of environmentally sensitive benzopyrylium-coumarin hybrid fluorophores which exist in equilibrium between a cyan fluorescent spirocyclic form and a NIR fluorescent zwitterionic form. As an RNA tag, we evolved a 38-nucleotide aptamer that selectively binds the zwitterionic forms with nanomolar affinity. We used this system as a light-up RNA marker to image mRNAs in the NIR region and demonstrated its utility in ratiometric analysis of target RNAs expressed at different levels in single cells.
ACYL SULFONAMIDES FOR TREATING CANCER
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Page/Page column 305, (2020/11/03)
The present invention provides acyl sulfonamide compounds of general formula (I): in which X, R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.
A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis
Fan, Li,Wang, Xiaodong,Ge, Jinyin,Li, Feng,Wang, Xiao,Wang, Juanjuan,Shuang, Shaomin,Dong, Chuan
supporting information, p. 4703 - 4706 (2019/05/02)
A lysosome-targeting and polarity-specific fluorescent probe CPM has been rationally designed for cancer diagnosis and imaging. We have successfully shown that lysosome polarity may serve as an ubiquitious marker for cancer detection. The potential of CPM for cancer diagnosis has also been demonstrated at the levels of live cells, organs, whole animal, and clinical patient tissue samples.
