132260-01-6

Basic information

• Product Name: ethyl 2-(5-phenylmethoxypyrimidin-2-yl)acetate
• Synonyms: ethyl 2-(5-phenylmethoxypyrimidin-2-yl)acetate
• CAS NO: 132260-01-6
• Molecular Weight: 272.304
• Mol File: 132260-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(5-phenylmethoxypyrimidin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5-phenylmethoxypyrimidin-2-yl)acetate(132260-01-6)
• EPA Substance Registry System: ethyl 2-(5-phenylmethoxypyrimidin-2-yl)acetate(132260-01-6)

Safety Data

• Hazardous Substances Data: 132260-01-6(Hazardous Substances Data)

Upstream product

• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 1114830-09-9 [(Z)-3-dimethylamino-2-phenylmethoxyprop-2-enylidene]dimethylazanium perchlorate 
• 75-36-5 acetyl chloride 

Downstream Products

• 948594-30-7 ethyl 2-(5-hydroxypyrimidin-2-yl)acetate 

Relevant articles and documents

An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate

The synthesis of methyl 2-(5-hydroxy-3-methoxypyridin-2-yl)acetate and alkyl 2-(5-hydroxypyrimidin-2-yl)acetate is described. Methodology for an efficient access to 5-hydroxy-pyridin- and pyrimidin-2-yl acetate cores has been developed. Based on the difference in halogen reactivity, 5-bromo-2-chloropyridine and its pyrimidine analogue were functionalized judiciously by SNAr and palladium-catalyzed reactions. The outlined strategy provides a high-yielding route suitable for large-scale synthesis of these compounds as well as paves the way for a potential rapid access to other heterocyclic analogues.