1322617-44-6

Basic information

• Product Name: N-(3-benzyl-4-(3-chlorophenylamino)-2-oxochroman-3-yl)benzamide
• CAS NO: 1322617-44-6
• Molecular Weight: 482.966
• Mol File: 1322617-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-benzyl-4-(3-chlorophenylamino)-2-oxochroman-3-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-benzyl-4-(3-chlorophenylamino)-2-oxochroman-3-yl)benzamide(1322617-44-6)
• EPA Substance Registry System: N-(3-benzyl-4-(3-chlorophenylamino)-2-oxochroman-3-yl)benzamide(1322617-44-6)

Safety Data

• Hazardous Substances Data: 1322617-44-6(Hazardous Substances Data)

Upstream product

• 65027-12-5 2-(benzylamino)-3-phenylpropanoic acid 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 886-32-8 m-chlorophenylsalicylaldimine 

Relevant articles and documents

Asymmetric synthesis of 3, 4-diaminochroman-2-ones promoted by guanidine and bisguanidium salt

A highly enantioselective synthesis of 3,4-diaminochroman-2-ones has been realized via the domino reaction of o-hydroxy aromatic aldimines and azlactones. Notably, a cis-product was obtained as the major product by the use of guanidine 2a whereas a trans-product was the major product with bisguanidium salt 3·HBArF 4. In two cases, various substituted 3,4-dihydrocoumarins were obtained with high yields (up to 99%) as well as excellent enantioselectivities (up to 99% ee) and diastereoselectivities (up to >99:1 cis:trans and 98:2 trans:cis, respectively) under mild reaction conditions.