53364-99-1

Basic information

• Product Name: N,N'-DI-P-TOSYL-1,3-DIAMINOPROPANE
• Synonyms: N,N'-DI-P-TOSYL-1,3-DIAMINOPROPANE;4-methyl-N-[3-[(4-methylphenyl)sulfonylamino]propyl]benzenesulfonamide
• CAS NO: 53364-99-1
• Molecular Formula: C₁₇H₂₂N₂O₄S₂
• Molecular Weight: 382.5
• Mol File: 53364-99-1.mol
• Article Data: 22

Chemical Properties

• Melting Point: 150-152 °C(lit.)
• Appearance: /
• CAS DataBase Reference: N,N'-DI-P-TOSYL-1,3-DIAMINOPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DI-P-TOSYL-1,3-DIAMINOPROPANE(53364-99-1)
• EPA Substance Registry System: N,N'-DI-P-TOSYL-1,3-DIAMINOPROPANE(53364-99-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 53364-99-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 109-64-8 1,3-dibromo-propane 
• 18522-92-4 sodium p-toluenesulfonamide 
• 109-76-2 Trimethylenediamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 60147-26-4 1,11-dioxa-4,8-bis(p-toluenesulphonyl)-4,8-diazacyclotridecane 
• 121821-31-6 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,3-propanediamine 
• 121821-30-5 N,N'-bis(4-phthalimidobutyl)-N,N'-ditosyl-1,3-propanediamine 
• 60147-25-3 4-oxa-1,7-bis(p-toluenesulphonyl)-1,7-diazacyclodecane 
• 176107-53-2 N,N'-bis(p-toluenesulfonamido)-N-(tert-butoxycarbonyl)-1,3-propanediamine 
• 73276-84-3 N,N′-(propane-1,3-diyl)bis(N-(2-hydroxyethyl)-4-methylbenzenesulfonamide) 
• 1006891-62-8 C₄₃H₅₂N₂O₆S₄ 
• 16077-33-1 1,3-ditosylhexahydro-1,3-diazine 
• 67761-04-0 1,5-bis(p-toluenesulphonyl)-1,5-diazacyclooctane 
• 99998-90-0 N,N'-(propane-1,3-diyl)bis(N,4-dimethylbenzenesulfonamide) 

Relevant articles and documents

Method for preparing diazacyclooctane intermediate and diazacyclooctane

The invention provides a method for preparing a diazacyclooctane intermediate and diazacyclooctane. The preparation method comprises the following steps: synthesizing 1,5-bis(p-toluenesulfonyl)-1,5-diazacyclooctane from 1,3-bis(p-toluenesulfonyl)-1,3-dioxypropane, 1,3-bis(p-toluenesulfonyl)-1,3-propane diamine and sodium methoxide under a temperature condition of 60-100 DEG C; then synthesizing 1,5-diazacyclooctane bromate from 1,5-bis(p-toluenesulfonyl)-1,5-diazacyclooctane, phenol and hydroacetic acid; and finally, synthesizing 1,5-diazacyclooctane from 1,5-diazacyclooctane bromate and sodium methoxide. According to the method, the yield of the 1,5-bis(p-toluenesulfonyl)-1,5-diazacyclooctane can be increased, and the reaction time for synthesizing the 1,5-diazacyclooctane can be shortened.

Gold-Catalyzed Regiodivergent [2 + 2 + 2]-Cycloadditions of Allenes with Triazines

Gold-catalyzed regiodivergent cycloadditions of functionalized allenes with 1,3,5-triazines, providing diverse N-heterocycles in moderate to excellent yields under mild reaction conditions, are reported. Importantly, different types of allenes exhibit distinct selectivity and reactivity for the reactions. Mechanistic investigations reveal that all of the cycloadditions proceed through a stepwise [2 + 2 + 2]-cycloaddition process.

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies

Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According to a two-site binding model, 28 new unsymmetrical analogues bearing a benzyl tail group and nine