132273-93-9

Upstream product

• 132273-87-1 (2R,4R)-2,N-dimethyl-4-phenyl-1,3-oxazolidine 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 84773-28-4 (R)-2-(methylamino)-2-phenylethanol 
• 56613-80-0 D-2-phenylglycinol 
• 131320-25-7 N-[(R)-2'-hydroxy-1'-phenylethyl]-(R)-1-phenyl-1-ethylamine 
• 74-88-4 methyl iodide 
• 917-54-4 methyllithium 
• 153924-63-1 β-[(phenylmethylene)amino]-[R-(E)-]-benzeneethanol 

Relevant academic research and scientific papers

Diastereoselective addition of chiral aliphatic imines and 2-alkyl-1,3-oxazolidines to organometallic reagents

The reaction of organocerium reagents with chiral aliphatic imines derived from (R)-O-methylphenylglycinol afforded the corresponding amines with high diastereoselectivity. In contrast, the reaction of Grignard reagents with chiral 2-alkyl-1,3-oxazolidines derived from (R)-N-methylphenylglycinol afforded the amines with changeover in diastereoselectivity.

DIASTEREOSELECTIVE ADDITION OF ORGANOMETALLIC REAGENTS TO CHIRAL IMINES AND 1,3-OXAZOLIDINES

The reaction of MeLi or MeMgBr with chiral aromatic imines and 2-aryl-1,3-oxazolidines derived from (R)-phenylglycinol afforded with good diastereoselectivity (R,R)-amines from imines, but the (R,S)-amines from 1,3-oxazolidines, respectively.