1322762-83-3Relevant academic research and scientific papers
Asymmetric synthesis of the C1-C6 portion of the psymberin using an Evans chiral auxiliary
Pal, Ashutosh,Peng, Zhenghong,Schuber Jr., Paul T.,Bhanu Prasad, Basvoju A.,Bornmann, William G.
supporting information, p. 5555 - 5557 (2013/09/23)
The C1-C6 region of the potent cytotoxic agent psymberin has been synthesized. The key transformations of the synthesis are an auxiliary-controlled addition of a Sn(II)-glycolate enolate to an aldehyde to yield the anti-aldol product and transforming the
Total synthesis of (+)-(2′S,3′R)-zoapatanol exploiting the B-alkyl Suzuki reaction and the nucleophilic potential of the sulfinyl group
Raghavan, Sadagopan,Sudheerbabu, Vaddela
experimental part, p. 8487 - 8494 (2011/09/12)
A stereoselective synthesis of the diterpenoid oxepane (+)-zoapatanol is described. The key steps include a B-alkyl Suzuki cross-coupling reaction for the stereoselective synthesis of trisubstituted alkenes, creation of the two stereogenic centers on the oxepane ring by heterofunctionalization of an alkene through substrate control exploiting the nucleophilic potential of an intramolecular sulfinyl group, and transformation of a β-hydroxy sulfoxide into a terminal alkene. Copyright
