13229-92-0Relevant articles and documents
Organo Photoinduced Decarboxylative Alkylation of Coumarins with N-(Acyloxy)phthalimide
Tripathi, Krishna N.,Belal, Md.,Singh, Ravi P.
, p. 1193 - 1201 (2020)
A metal-free and mild, photoinduced decarboxylative 4-position alkylation of coumarins has been reported. Photoinduced single electron transfer has been initiated by utilizing the visible-light absorptivity of Eosin Y for a reductive generation of alkyl r
Iodine-mediated one-pot synthesis of 3-cyanocoumarins and 3-cyano-4-methylcoumarins
Sharma, Dinesh,Makrandi, Jagdish K.
, p. 527 - 531 (2014)
2-Hydroxybenzaldehydes 1a-e on reaction with malononitrile (2) in the presence of iodine as catalyst give 3-cyanocoumarins 3a-e in one step under thermal heating as well as under microwave irradiation. The latter conditions are much more efficient in terms of time (2-5 min) and yield as compared to the thermal conditions (2-2.5 h). Following a similar procedure, 3-cyano-4-methylcoumarins 3f-i were also prepared by the reaction of 2-hydroxyacetophenones 1f-i with 2.
Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis
Da Silveira Pinto, Ligia S.,De Souza, Marcus V. N.
, p. 2677 - 2682 (2017)
This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.
Investigation of the Relationship between H2O2 and HClO in Living Cells by a Bifunctional, Dual-ratiometric Responsive Fluorescent Probe
Han, Jinliang,Liu, Xingjiang,Song, Xiangzhi,Wang, Benhua,Wang, Jingpei,Wang, Wei,Xiong, Haiqing
, p. 5134 - 5142 (2020)
As two important reactive oxygen species, hydrogen peroxide (H2O2) and hypochlorous acid (HClO) play vital roles in many physiological and pathological processes. However, the relationship between these two species is seldom investigated, in part, because
ZrCl4/[bmim]BF4-catalyzed condensation of salicylaldehydes and malononitrile: Single-step synthesis of 3-cyanocoumarin derivatives
Valizadeh, Hassan,Mahmoodian, Manzar,Gholipour, Hamid
, p. 799 - 802 (2011)
Figure represented. A versatile and efficient single-step route to 3-cyanocoumarins via Knoevenagel condensation of salicylaldehydes and malononitrile using ZrCl4 as the catalyst (15 mol %) in ionic liquid 1-(n-butyl)-3-methylimidazolium tetrafluoroborate as reaction medium and catalyst is described. The novel procedure features single step, short reaction time, good yields, and simple workup.
One-Pot Synthesis of 3-Carboxycoumarins via Consecutive Knoevenagel and Pinner Reactions in Water
Fringuelli, Francesco,Piermatti, Oriana,Pizzo, Ferdinando
, p. 2331 - 2334 (2003)
Chloro-, hydroxy-, methoxy-, and tert-butyl-substituted 3-carboxycoumarins have been prepared by one-pot procedure by reaction of suitably substituted salicylaldehydes with malononitrile in water. The over-all yields are high and the protocol does not require organic solvents.
One-Pot Green Synthesis of 2-Oxo-2H-chromene-3-carbonitriles Using Dual-Frequency Ultrasonication
Aruna,Kumar, S.,Sharma, S. P.,Vashisht, N.
, p. 1508 - 1512 (2021/10/26)
Abstract: A green synthesis of 2-oxo-2H-chromene-3-carbonitriles has been carried out in one step by reacting 2-hydroxybenzaldehydes or 2-hydroxyacetophenones with ethyl cyanoacetate under dual-frequency ultrasonica-tion (ultrasonic bath of 40 KHz and probe of 20 KHz). The compounds were obtained in very high yield, and their structures were confirmed by IR and NMR data.
Coumarin derivatives act as novel inhibitors of human dipeptidyl peptidase III: Combined in vitro and in silico study
?ubari?, Domagoj,Agi?, Dejan,Be?lo, Drago,Kara?i?, Zrinka,Karna?, Maja,Lisjak, Miroslav,Lon?ari?, Melita,Molnar, Maja,Popovi?, Boris M.,Rastija, Vesna,Tomi?, Sanja
, (2021/06/22)
Dipeptidyl peptidase III (DPP III), a zinc-dependent exopeptidase, is a member of the metalloproteinase family M49 with distribution detected in almost all forms of life. Although the physiological role of human DPP III (hDPP III) is not yet fully elucida
FeCl3-catalyzed cascade reaction: An efficient approach to functionalized coumarin derivatives
He, Xinwei,Yan, Zhenglei,Hu, Xiaoqian,Zuo, Yin,Jiang, Chang,Jin, Lei,Shang, Yongjia
supporting information, p. 1507 - 1514 (2014/05/20)
An efficient and environmentally benign synthesis of 3-substituted or 3,4-disubstituted coumarins was accomplished via iron(III) chloride-catalyzed cascade reactions of salicylaldehydes and activated methylene compounds. The reaction preceded cleanly under mild reaction conditions to provide the desired coumarin derivatives in good to excellent yields.
Synthesis of new iminocoumarins and their transformations into N-chloro and hydrazono compounds
Volmajer, Julija,Toplak, Renata,Leban, Ivan,Le Marechal, Alenka Majcen
, p. 7012 - 7021 (2007/10/03)
The Knoevenagel reaction between 2-hydroxybenzaldehydes and active methylene compounds (malononitrile and ethyl cyanoacetate) produces iminocoumarins and/or coumarins. In order to study the reactivity of the prepared iminocoumarins, chlorination and reaction with N-nucleophiles were studied.
