13229-93-1Relevant academic research and scientific papers
Knoevenagel condensation catalyzed by a tertiary-amine functionalized polyacrylonitrile fiber
Li, Guowei,Xiao, Jia,Zhang, Wenqin
, p. 1828 - 1836 (2011)
A new fiber catalyst for Knoevenagel condensation has been prepared by aminating a commercially available polyacrylonitrile fiber with N,N-dimethyl-1,3-propanediamine. The fiber catalyst was characterized by elemental analysis, X-ray powder diffraction spectra (XRD), scanning electron microscopy (SEM) and Fourier-transfer infrared spectroscopy (FTIR). The Knoevenagel condensation proceeded smoothly in the presence of the fiber catalyst and the products were obtained in excellent yields. This catalyst is applicable to a wide range of aromatic aldehydes. Moreover, the reaction can be easily carried out in different solvents of varying polarities. The newly developed fiber catalyst was also found to exhibit excellent recyclability and reusability (up to 10 times) without any additional treatment.
Mechanistic perspectives on piperidine-catalyzed synthesis of 1,5-benzodiazepin-2-ones
Mansour, Hanaa,El-Hendawy, Morad M.
, (2020)
This work introduced new members to the pharmaceutical family of 1,5-benzodiazepin-2-ones, 2a–e. These compounds were synthesized in moderate yields via the reaction of 1,2-bifunctional substrates (α-cyanocinnamates) with o-phenylenediamine in
Efficient preparation of Zr(IV)-salen grafted mesoporous MCM-41 catalyst for chemoselective oxidation of sulfides to sulfoxides and Knoevenagel condensation reactions
Hajjami, Maryam,Ghorbani, Farshid,Rahimipanah, Sedighe,Roshani, Safoora
, p. 1852 - 1860 (2015)
Zr(IV)-salen-MCM-41 was prepared by reaction of NH2-MCM-41 with salicylaldehyde to afford Schiff base ligands. Thereafter, ZrOCl2·8H2O was reacted with the Schiff base ligands for complex formation. The structural properti
Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation
Datta, Arup
, p. 843 - 849 (2020/11/25)
In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]
Hypervalent Iodine(III)-Catalyzed Epoxidation of β-Cyanostyrenes
Mangaonkar, Saeesh R.,Singh, Fateh V.
, p. 4473 - 4486 (2019/11/21)
A convenient approach for the synthesis of β-cyanoepoxides is illustrated by iodine(III)-catalyzed epoxidation of electron-deficient β-cyanostyrenes, wherein the active catalytic iodine(III) species was generated in situ. The epoxidation of β-cyanostyrenes was performed using 10 molpercent PhI as precatalyst in the presence of 2.0 equivalents Oxone as an oxidant and 2.4 equivalents of TFA as an additive at room temperature under ultrasonic radiations. The β-cyanoepoxides were isolated in good to excellent yields in a short reaction time.
Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water
Yang, Pengkun,Liu, Yawei,Chai, Ling,Lai, Zhenzhen,Fang, Xiaomin,Liu, Baoying,Zhang, Wenkai,Lu, Minghua,Xu, Yuanqing,Xu, Hao
supporting information, p. 1060 - 1067 (2018/05/23)
A series of novel N-methyl piperidine (Nmp)-based ionic liquids with 1,2-propanediol group are synthesized and used as catalysts for both hetero-Michael addition of α,β-unsaturated amides and Knoevenagel condensation at room temperature in water; and all the examined substrates could be transformed into corresponding products in good to excellent yields. Meanwhile IL-catalyzed hetero-Michael addition of α,β-unsaturated amides in water has not been reported in the previous literatures. Additionally, the catalyst is recyclable for the two reactions. This finding provides a green catalyst for both hetero-Michael addition of α,β-unsaturated amides and Knoevenagel condensation in water.
New synthetic protocol for stereoselective synthesis of diethyl 1,2-dicyano-3-alkyl-(aryl)cyclopropane-1,2-dicarboxylate
Noroozi Pesyan, Nader,Golizadeh, Saeed
, p. 1261 - 1273 (2015/06/02)
Abstract A new, fast and straightforward method for the one-pot reaction of aromatic and aliphatic aldehydes and dialdehydes with ethyl cyanoacetate and cyanogen bromide was developed to afford stereoselectively diethyl 1,2-dicyano-3-alkyl/arylcyclopropan
Efficient and reusable amine-functionalized polyacrylonitrile fiber catalysts for Knoevenagel condensation in water
Li, Guowei,Xiao, Jia,Zhang, Wenqin
experimental part, p. 2234 - 2242 (2012/09/10)
A series of new fiber catalysts has been synthesized by aminating a commercially available polyacrylonitrile fiber with polyamines such as diethylenetriamine and triethylenetetramine. These fiber catalysts can efficiently catalyze the Knoevenagel condensation of benzaldehyde and ethyl cyanoacetate in water (yields: 95-98%). The triethylenetetramine aminated fiber catalyst was used to catalyze the condensations of a wide range of aromatic aldehydes and active methylene compounds and in each case, this catalyst performed well with yields higher than 93%. This fiber catalyst also exhibited excellent reusability (up to 21 times) and photostability.
Lipase-catalysed tandem Knoevenagel condensation and esterification with alcohol cosolvents
Lai, Yi-Feng,Zheng, Hui,Chai, She-Jie,Zhang, Peng-Fei,Chen, Xin-Zhi
supporting information; experimental part, p. 1917 - 1918 (2010/12/24)
Six lipases were screened for their ability to catalyse the Knoevenagel condensation between benzaldehyde and methyl cyanoacetate. Lipase from porcine pancreas tolerated a variety of functional groups on the aromatic ring, produced the highest yields, and
A simple, efficient and green procedure for the Knoevenagel condensation of aldehydes with N-methylpiperazine at room temperature under solvent-free conditions
Mukhopadhyay, Chhanda,Datta, Arup
, p. 2103 - 2112 (2008/09/21)
Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions in the presence of N-methylpiperazine in excellent yields of the E-configured products. Copyright Taylor & Francis Group, LLC.
