13230-06-3

Upstream product

• 13230-44-9 1-benzyl-2-methyl-5-nitro-1H-imidazole 
• 100-44-7 benzyl chloride 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 100-39-0 benzyl bromide 

Downstream Products

• 41604-61-9 5-Bromo-2-methyl-4-nitro-1-(phenylmethyl)-1H-imidazole 
• 256530-58-2 1-Benzyl-5-dichlormethyl-2-methyl-4-nitroimidazol 
• 107108-05-4 5-(Cyano-4-morpholinylphenylmethyl)-2-methyl-4-nitro-1-(phenylmethyl)-1H-imidazole 
• 107108-07-6 (2-Methyl-4-nitro-1-(phenylmethyl)-1H-imidazol-5-yl)phenylmethanone 
• 256530-69-5 4-(1-Benzyl-2-methyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester 
• 256530-63-9 4-(1-Benzyl-2-methyl-4-nitro-imidazol-5-yl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester 
• 256530-60-6 1-Benzyl-2-methyl-4-nitroimidazol-5-carbaldehyd 

Relevant academic research and scientific papers

Solid-liquid phase-transfer catalytic method for N-alkylation of nitroimidazole

A variety of 1-alkyl-2-methyl-4-nitroimidazoles have been synthesized with a solid-liquid phase-transfer catalytic method in excellent yields.

A facile high yielding method for synthesis of N-alkyl-4-nitroimidazoles

A high yielding and fast reaction for the synthesis of a variety of N-alkyl 4-nitroimidazoles has been described. This method involves reaction of 2-methyl-4(5)-nitro-1H-imidazole with suitable alkyl halides in K2CO3/DMF at 110-120°C.

Regioselective Alkylation of 4(5)-Nitro-1H-Imidazoles in Acidic Media: Study of Temperature Effects

Alkylation of 4(5)-nitro-1H-imidazoles in acidic media with reactive alkylating agents such as benzyl chloride and allyl bromide resulted in the predominant formation of the 5-nitro isomers at lower temperatures (75 deg C) and the 4-nitro isomers at higher temperatures (140 deg C).With less reactive alkylating agents, only the 5-nitro isomers were produced irrespective of temperature.The mechanism was shown to involve quaternization of the initially formed 1-alkyl-5-nitro-1H-imidazoles followed by preferential dealkylation to yield the thermodynamically more stable 4-nitro-1H-imidazoles.