13230-22-3

Basic information

• Product Name: ethyl 2-(2-methyl-4-nitro-imidazol-1-yl)acetate
• Synonyms: ethyl 2-(2-methyl-4-nitro-imidazol-1-yl)acetate;1-(Carbethoxymethyl)-2-methyl-4-nitroimidazole;2-Methyl-4-nitro-1H-imidazole-1-acetic acid ethyl ester
• CAS NO: 13230-22-3
• Molecular Formula: C8H11N3O4
• Molecular Weight: 213.19
• Mol File: 13230-22-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 112 °C
• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 188°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 3.33E-06mmHg at 25°C
• Refractive Index: 1.573
• PKA: 0.54±0.60(Predicted)
• CAS DataBase Reference: ethyl 2-(2-methyl-4-nitro-imidazol-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-methyl-4-nitro-imidazol-1-yl)acetate(13230-22-3)
• EPA Substance Registry System: ethyl 2-(2-methyl-4-nitro-imidazol-1-yl)acetate(13230-22-3)

Safety Data

• Hazardous Substances Data: 13230-22-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11N3O4/c1-3-15-8(12)5-10-4-7(11(13)14)9-6(10)2/h4H,3,5H2,1-2H3

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 
• 551-92-8 dimetridazole 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 16230-87-8 1-carboxymethyl-2-methyl-4-nitroimidazole 
• 93637-76-4 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetohydrazide 
• 72896-08-3 (5-bromo-2-methyl-4-nitro-imidazol-1-yl)-acetic acid ethyl ester 
• 93637-70-8 (2-Methyl-4-nitro-imidazol-1-yl)-acetic acid [1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-meth-(E)-ylidene]-hydrazide 
• 302807-92-7 5-bromo-1-carboxymethyl-2-methyl-4-nitroimidazole 

Relevant articles and documents

Synthesis, crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus

Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.

Synthesis of 7-methyl-6-(nitroimidazolyl)thiopurines

We have studied the reactions of 7-methyl-6-thiopurine with 5(4)-halo-4(5)-nitroimidazoles and 6-chloro-7-methylpurine with sodium and ammonium salts of 5-mercapto-4-nitroimidazoles. We have obtained a series of 7-methyl-6-(nitroimidazolyl)thiopurines not previously described in the literature.

IMIDAZOLE DERIVATIVES: XVIII. SYNTHESIS AND ANTITUMOR ACTIVITY OF SOME BISAMINO IMIDAZOLE DERIVATIVES

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