1323153-46-3Relevant academic research and scientific papers
Xanthones in heterocyclic synthesis. An efficient and general route for the synthesis of regioselectively substituted phthalazines
Gardikis, Yiannis,Tsoungas, Petros G.,Potamitis, Constantinos,Pairas, George,Zervou, Maria,Cordopatis, Paul
, p. 1291 - 1302 (2011/06/27)
Xanthone undergoes regioselective substitution and nucleophically - triggered ring opening to the corresponding ketone. Hydrazone of the latter oxidatively rearranges to ortho-diacylarenes, which, then, with hydrazine gives regioselectively substituted phthalazines. Molecular modeling analysis and 1HNMR spectra indicate an intramolecular H-bonding engaging phenol OH and phthalazine N-3 atom.
