20061-59-0Relevant academic research and scientific papers
Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor
Kralj, Ana,Kurt, Elif,Tschammer, Nuska,Heinrich, Markus R.
, p. 151 - 168 (2014/01/17)
To prepare and biologically evaluate 38 new potential US28 allosteric modulators, we employed a straightforward synthetic route involving radical arylation. The study was based on a former lead structure but with the dihydroisoquinolinone moiety replaced by substituted biphenyls. The investigation of structure-activity relationships among the new biphenyl-derived ligands led to a preliminary pharmacophore model and the discovery of four promising candidates with full inverse agonist properties. Hit HCMV GPCRs ASAP! Employing a straightforward synthetic access involving radical arylation, 38 new potential US28 allosteric modulators were prepared and biologically evaluated. The investigation of structure-activity relationships among the new biphenyl-derived ligands led to a consistent model and the discovery of four promising candidates with full inverse agonist properties. Copyright
Synthesis and antimycobacterial activity of nitroxanthones. 1st Communication: Synthesis and differential scanning calorimetry analysis
Ibrom, Wolfgang G. A.,Frahm, August W.
, p. 662 - 667 (2007/10/03)
The syntheses of mono-, di-, tri- and tetranitroxanthones via intramolecular Friedel-Crafts acylation of nitrated 2-phenoxybenzoic acids as well as via selective stepwise nitration of xanthone and the nitroxanthones gained from the first route are describ
Pyrazolobenzazepines
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, (2008/06/13)
There are presented compounds of the formulas STR1 wherein R1 is hydrogen or lower alkyl; R2 and R3 are selected from the group consisting of hydrogen, lower alkyl, C2 to C7 carboxylic acids, hydroxy
