1323276-69-2

Upstream product

• 1323276-66-9 tert-butyl 2-(3-(4-hydroxyphenyl)ureido)ethylcarbamate 
• 312-68-5 3-fluoropropyl tosylate 
• 50528-73-9 4-benzyloxy-phenyl isocyanate 
• 57260-73-8 N-BOC-1,2-diaminoethane 

Downstream Products

• 1037411-67-8 (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(4-(3-fluoropropoxy) phenyl)urea 
• 1037412-37-5 1-(2-aminoethyl)-3-[4-(3-fluoropropoxy)-phenyl]-urea 

Relevant academic research and scientific papers

Synthesis and cardiac imaging of 18F-ligands selective for β1-adrenoreceptors

A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/ β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribution studies demonstrated uptake of each radiotracers from the blood pool into the myocardium (0.48-0.62% ID/g), lung (0.63-0.97% ID/g), and liver (1.03-1.14% ID/g). Dynamic μPET imaging confirmed the in vivo dissection studies.