1323293-44-2Relevant academic research and scientific papers
Correlation of spectroscopically determined ligand donor strength and nucleophilicity of substituted pyrazoles
Bernhammer, Jan Christopher,Huynh, Han Vinh
, p. 8600 - 8608 (2012/10/07)
The relative ligand donor strengths of 10 pyrazole-derived ligands has been determined with great accuracy, making use of the interdependence between the donor strength of the co-ligand and the 13C NMR chemical shift of the iPr2-bimy carbene signal in trans-[PdBr2( iPr2-bimy)L] complexes (iPr2-bimy = 1,3-diisopropylbenzimidazolin-2-ylidene; L = pyrazole-derived ligand). Even subtle variations in the substitution pattern of the pyrazole backbone up to three bonds away from the coordinating nitrogen could be detected reliably using this methodology. Alkylation experiments conducted on the pyrazoles using electrophiles of varied reactivity (ethyl bromide, ethyl iodide, and trimethyloxonium tetrafluoroborate) served as a benchmark to rank the pyrazoles in three groups of gradually increasing nucleophilicity, which correlated well with their determined donor strength.
Direct synthesis of polysubstituted aluminoisoxazoles and pyrazoles by a metalative cyclization
Jackowski, Olivier,Lecourt, Thomas,Micouin, Laurent
supporting information; experimental part, p. 5664 - 5667 (2011/12/04)
Alumino-heteroles are obtained from simple precursors in a fully chemo- and regioselective manner by a metalative cyclization. The carbon-aluminum bond is still able to react further with several electrophiles, without the need of transmetalation. This sy
