132336-35-7Relevant academic research and scientific papers
Synthesis and purification method of antiviral drug key intermediate
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, (2020/05/01)
The invention discloses a synthesis and purification method of a key intermediate (s)-N4-benzoyl-N-[(2-phosphomethoxy-3-hydroxy)propyl]cytosine of an antiviral drug (s)-N-[(2-phosphomethoxy-3-hydroxy)propyl]cytosine. The key intermediate is synthesized from (s)-N4-benzoyl-N-[(2-diethylphosphate-3-triphenoxy)propyl]cytosine in one step under the catalysis of 40% HBr. After a reaction is finished, the pH value is adjusted to be 7, and filtering is carried out to obtain a crude product; and the crude product is recrystallized at 100 DEG C to obtain the refined product.
Method for synthesizing antiviral drugs cidofovir and buciclovir
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, (2019/01/06)
The invention relates to a method for synthesizing antiviral drugs, i.e., cidofovir and buciclovir, belonging to the field of asymmetric synthesis in organic chemistry. According to the invention, pyrimidine with position 1 substituted by an allyl group or purine with position 9 substituted by a butenyl group are used as raw materials and subjected to asymmetric dihydroxylation so as to obtain a key chiral intermediate of cidofovir or buciclovir, and then a multi-step reaction is carried out so as to obtain cidofovir or buciclovir. With such a route in the invention, the reaction raw materialsare easily available, stereoselectivity is high, and the chiral dihydroxynucleoside intermediates are obtained after the reaction, and the cidofovir and buciclovir can be smoothly obtained after multiple steps of transformation.
A Practical Synthesis of (S)-HPMPC
Brodfuehrer, Paul R.,Howell, Henry G.,Sapino, Chester Jr.,Vemishetti, Purushotham
, p. 3243 - 3246 (2007/10/02)
Synthesis of the title nucleotide was accomplished in high yield starting from (S)-tritylglycidol (5) and N-benzoylcytosine (9).
