Contribution of inward rectifier K+ currents (IK1) and ATP-sensitive K+ currents (IKATP) to membrane potential changes of ventricular myocytes appearing during hypotonic challenge is unclear. We used here the whole cell patch clamp technique, voltage and current clamp modes, to record membrane p...detailed
The maximal responses (Emaxs) of isolated rat gastric fundus strips to 300 nm porcine galanin (Gal) were decreased in a concentration-dependent manner by terikalant (RP 62719). EC50of the agent equalled 4.39 μm (2.35–8.22). On the contrary the action of 30 n m of carbachol were not affected by...detailed
The proarrhythmic activities of the selective IKr blocker erythromycin and the less selective K+ channel blockers, terikalant and clofilium, have been compared in an α1-adrenoceptor-stimulated, anaesthetized rabbit model. Terikalant (2.5, 7.5 and 25 nmol kg−1 min−1; n=10), erythromycin (133, 40...detailed
The cellular mechanism of action of terikalant, an investigational antiarrhythmic agent known to block the inward rectifier and other potassium currents, has not yet been fully clarified. The aim of the present study was therefore to analyse the in vitro electrophysiological effects of terikalan...detailed