THE INHIBITORY EFFECTS OF Terikalant (cas 132338-79-5) ON THE CONTRACTILE ACTIVITY OF GALANIN IN ISOLATED RAT FUNDUS STRIPS
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Add time:08/07/2019 Source:sciencedirect.com
The maximal responses (Emaxs) of isolated rat gastric fundus strips to 300 nm porcine galanin (Gal) were decreased in a concentration-dependent manner by Terikalant (cas 132338-79-5) (RP 62719). EC50of the agent equalled 4.39 μm (2.35–8.22). On the contrary the action of 30 n m of carbachol were not affected by the modulator in concentrations up to 30 μm. It is concluded that potassium currents may contribute to the modulation of Gal myotropic activity in the gut.
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