1323394-01-9Relevant articles and documents
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy) propyl]nucleoside alkoxyalkyl esters: Inhibitors of hepatitis C virus and HIV-1 replication
Valiaeva, Nadejda,Wyles, David L.,Schooley, Robert T.,Hwu, Julia B.,Beadle, James R.,Prichard, Mark N.,Hostetler, Karl Y.
, p. 4616 - 4625 (2011)
We reported previously that octadecyloxyethyl 9-(S)-[3-hydroxy-2- (phosphonomethoxy)-propyl]adenine (ODE-(S)-HPMPA) was active against genotype 1b and 2a hepatitis C virus (HCV) replicons. This is surprising because acyclic nucleoside phosphonates have be
PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS
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Page/Page column 56, (2011/11/01)
There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds fo