4016-11-9

Usage

Uses

Used in Chemical Synthesis:
ETHYL GLYCIDYL ETHER is used as a chemical intermediate for the synthesis of various compounds, such as glycidyl ethers and epoxides, due to its reactive epoxy and ethyl groups.
Used in Pharmaceutical Industry:
ETHYL GLYCIDYL ETHER is used as a starting material for the production of pharmaceutical compounds, as its chemical properties allow for the creation of diverse drug molecules with potential therapeutic applications.
Used in Coatings and Adhesives:
ETHYL GLYCIDYL ETHER is used as a reactive diluent in the coatings and adhesives industry, where its ability to polymerize helps improve the performance and properties of the final products.
Used in Composite Materials:
ETHYL GLYCIDYL ETHER is used as a component in the manufacturing of composite materials, where its polymerization properties contribute to the formation of strong and durable materials.
Used in Surface Treatments:
ETHYL GLYCIDYL ETHER is used in surface treatments, such as adhesion promoters and coupling agents, to enhance the bonding between different materials, like plastics, metals, and ceramics.
Used in Electronic Industry:
ETHYL GLYCIDYL ETHER is used in the electronic industry as a component in the production of encapsulants and potting compounds, which protect electronic components from environmental factors and mechanical stress.

Air & Water Reactions

Highly flammable. Soluble with possible partial decomposition in water.

Reactivity Profile

An epoxide and ether. Ethers can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Mutation data reported. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.

Potential Exposure

It has limited commercial use in organic synthesis.

Shipping

UN2752 1,2-Epoxy-3-ethoxypropane, Hazard Class: 3; Labels: 3-Flammable liquid

Incompatibilities

Polymerizable. Keep away from strong oxidizers, heat, flames

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

InChI:InChI=1/C5H10O2/c1-2-6-3-5-4-7-5/h5H,2-4H2,1H3/t5-/m1/s1

Upstream product

• 4151-98-8 1-ethoxy-3-chloro-propan-2-ol 
• 2425-31-2 1-bromo-3-ethoxy-propan-2-ol 
• 64-17-5 ethanol 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 557-31-3 3-ethoxyprop-1-ene 

Downstream Products

• 18282-78-5 γ-Ethoxy-β-hydroxy-butyronitril 
• 37742-82-8 N,N-bis-(3-ethoxy-2-hydroxy-propyl)-aniline 
• 13021-50-6 1-ethoxy-3-isopropoxy-2-propanol 
• 35152-18-2 1-amino-3-ethoxy-propan-2-ol 
• 75-56-9 methyloxirane 
• 690-39-1 1,1,1,3,3,3-hexafluoropropane 
• 62498-14-0 trans-1,3-bis(perfluoro-tert-butyl)propene 
• 75-21-8 oxirane 
• 4151-98-8 1-ethoxy-3-chloro-propan-2-ol 
• 856245-86-8 7,8-bis(4-chlorophenyl)-2-(3-ethoxy-2-hydroxypropyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one 
• 1236766-20-3 3-[4-(Cyclopropylmethoxy)phenyl]-2-[(3-ethoxy-2-hydroxypropyl)sulfanyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties

It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.

Diastereoselective Desymmetrization of p-Quinamines through Regioselective Ring Opening of Epoxides and Aziridines

A highly diastereoselective desymmetrization of p-quinamines via regioselective ring opening of epoxides and aziridines under mild conditions has been developed. A chairlike six-membered transition state with minimized 1,3-diaxial interactions explains the relative stereoselectivity of the cyclization reaction. This transition-metal free [3 + 3] annulation reaction provides rapid access to fused bicyclic morpholines and piperazines with a tetrasubstituted carbon center in high yields. In addition, it also allows the synthesis of enantioenriched products by using easily accessible chiral nonracemic epoxides and aziridines.

hybrid-fluorinated non-ionic surfactant with short perfluoroalkyl chains and preparation method thereof

The present invention relates to a hybrid fluorine-based nonionic surfactant containing a short fluorinated alkyl group, and a preparing method thereof, and more particularly, to a hybrid fluorine-based nonionic surfactant having one low fluorinated alkyl group and one hydrocarbon group, and a preparing method thereof. According to the present invention, the hybrid fluorine-based nonionic surfactant realizes a low surface tension and CMC even though a short fluorinated alkyl group is included in one molecule, and has high solubility in water and excellent emulsification stability, and thus has excellent physical properties as a surfactant. In addition, the hybrid fluorine-based nonionic surfactant is less harmful to the human body and the environment compared to a conventional surfactant due to low fluorinated alkyl group, and requires low manufacturing costs and thus can be beneficially used as an eco-friendly and economical fluorine-based nonionic surfactant having competitiveness in terms of price. In particular, the hybrid fluorine-based nonionic surfactant of the present invention can be beneficially used as a surfactant replacing a conventional fluorine-based nonionic surfactant containing a long perfluorinated alkyl group such as PFOA or PFOS known to be harmful to the environment and the human body.COPYRIGHT KIPO 2018

Mechanism of preferential enrichment, an unusual enantiomeric resolution phenomenon caused by polymorphic transition during crystallization of mixed crystals composed of two enantiomers

The mechanism of Preferential Enrichment, an unusual enantiomeric resolution phenomenon observed upon recrystallization of a series of racemic crystals which are classified as a racemic mixed crystal with fairly ordered arrangement of the two enantiomers, has been studied. On the basis of the existence of polymorphs and the occurrence of the resulting polymorphic transition during crystallization from solution, the mechanism has been accounted for in terms of (1) a preferential homochiral molecular association to form one-dimensional chain structures in the supersaturated solution of the racemate or nonracemic sample with a low ee value, (2) a kinetic formation of a metastable crystalline phase retaining the homochiral chain structures in a process of nucleation, (3) a polymorphic transition from the metastable phase to a stable one followed by enantioselective liberation of the excess R (or S) enantiomers from the transformed crystal into solution at the beginning of crystal growth to result in a slight enrichment (up to 10% ee) of the opposite S (or R) enantiomer in the deposited crystals, together with an enantiomeric enrichment of the R (or S) enantiomer in the mother liquor, and (4) a chiral discrimination by the once formed S (or R)-rich stable crystalline phase in a process of the subsequent crystal growth, leading to a considerable enantiomeric enrichment of the R (or S) enantiomer up to 100% ee in the mother liquor. The processes (3) and (4) are considered to be directly responsible for an enrichment of one enantiomer in the mother liquor. The association mode of the two enantiomers in solution has been investigated by means of (i) the solubility measurement and (ii) the number-averaged molecular weight measurement in solution by vapor pressure osmometry, together with (iii) the molecular dynamics simulation of oligomer models. The polymorphic transition during crystallization has been observed visually and by means of the in situ FTIR technique and DSC measurement. Both metastable and stable crystals have been obtained, and their crystal structures have been elucidated by X-ray crystallographic analysis of their single crystals.

LE CHLOROALLYLLITHIUM COMME SYNTHON DE CHLOROALLYLATION OU COMME EQUIVALENT DU VINYLCARBENE: SYNTHESE REGIOSELECTIVE D'ALCOOLS γ-ETHYLENIQUES β-CHLORES ET DE VINYL-2 OXETANES A PARTIR D'EPOXYDES

Chloroallyllithium reacts regioselectively with various epoxides in a "one-pot" reaction to produce either γ-ethylenic β-chloro alcohols or 2-vinyl oxetanes, depending on the experimental conditions used.

An Electron Spin Resonance Study of 3-Oxypropenoyl Radicals derived from Glycidols

Glycidols with blocked OH groups (A; M = alkyl or trialkylsilyl) react with t-butoxyl radicals to show the e.s.r. spectra of the corresponding 3-oxypropenoyl radicals (D), and 24 examples of these acyl radicals are reported.The reaction is thought to proceed through the formation of the allyloxyl radicals (B), which, in part, are converted into the aldehyde (C) which is very reactive towards loss of hydrogen to give the acyl radical (D).Glycidyl pivalate (A; M = COCMe3) reacts cleanly in this way, but glycidyl acetate (E; R = Me) also undergoes intramolecular 1,5-transfer of the acyl group to show the spectrum of the enoxyl radical (F).Glycidyl propionate and butyrate do not undergo this acyl transfer, but show the spectra of the radicals and (R' = Me or Et).