4016-11-9

Basic information

• Product Name: ETHYL GLYCIDYL ETHER
• Synonyms: 1,2-epoxy-3-ethoxy-propan;1,2-Epoxy-3-ethyloxy propane;2-(Ethoxymethyl)oxirane;3-Ethoxy-1,2-epoxypropane;Propane, 1,2-epoxy-3-ethoxy-;1-ETHOXY-2,3-EPOXYPROPANE;ETHYL GLYCIDYL ETHER;Oxiranylmethylethyl ether
• CAS NO: 4016-11-9
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.13
• EINECS: 223-671-3
• Product Categories: Oxiranes;Simple 3-Membered Ring Compounds
• Mol File: 4016-11-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 128 °C
• Flash Point: 47 °C
• Appearance: Clear colorless/Liquid
• Density: 0.94
• Vapor Pressure: 11.9mmHg at 25°C
• Refractive Index: 1.4075-1.4095
• Storage Temp.: Flammables area
• CAS DataBase Reference: ETHYL GLYCIDYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL GLYCIDYL ETHER(4016-11-9)
• EPA Substance Registry System: ETHYL GLYCIDYL ETHER(4016-11-9)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-10-51/53-36-22
• Safety Statements: 37/39-26-16-61
• RIDADR: 2752
• RTECS: TZ3200000
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 4016-11-9(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 4016-11-9 differently. You can refer to the following data:
1. clear colorless liquid
2. Epoxy ethyloxy propane is a colorless, highly flammable, polymerizable liquid

General Description

A colorless liquid. Flash point near 100°F. Less dense than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption.

Air & Water Reactions

Highly flammable. Soluble with possible partial decomposition in water.

Reactivity Profile

An epoxide and ether. Ethers can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Mutation data reported. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.

Potential Exposure

It has limited commercial use in organic synthesis.

Shipping

UN2752 1,2-Epoxy-3-ethoxypropane, Hazard Class: 3; Labels: 3-Flammable liquid

Incompatibilities

Polymerizable. Keep away from strong oxidizers, heat, flames

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

InChI:InChI=1/C5H10O2/c1-2-6-3-5-4-7-5/h5H,2-4H2,1H3/t5-/m1/s1

Upstream product

• 4151-98-8 1-ethoxy-3-chloro-propan-2-ol 
• 2425-31-2 1-bromo-3-ethoxy-propan-2-ol 
• 557-31-3 3-ethoxyprop-1-ene 
• 64-17-5 ethanol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 106-89-8 epichlorohydrin 

Downstream Products

• 18282-78-5 γ-Ethoxy-β-hydroxy-butyronitril 
• 26798-84-5 C₂₁H₃₅Cl₃O₆Si 
• 1375419-02-5 2-chloro-N-[2-ethoxymethyl-4-(4-fluorobenzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-6-trifluoromethylbenzamide 
• 1323394-01-9 (RS)-9-[(3-ethoxy-2-hydroxy)propyl]-6-O-benzylguanine 
• 1323394-07-5 C₃₇H₆₁N₅O₇P^(1-)*Na⁽¹⁺⁾ 
• 1323393-82-3 hexadecyloxypropyl (R,S)-9-[3-ethoxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine sodium salt 
• 1323393-75-4 (RS)-9-[(3-ethoxy-2-hydroxy)propyl]-N₆-(p-monomethoxytrityl)adenine 
• 1236766-20-3 3-[4-(Cyclopropylmethoxy)phenyl]-2-[(3-ethoxy-2-hydroxypropyl)sulfanyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 856245-86-8 7,8-bis(4-chlorophenyl)-2-(3-ethoxy-2-hydroxypropyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one 

Relevant articles and documents

Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties

It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.

hybrid-fluorinated non-ionic surfactant with short perfluoroalkyl chains and preparation method thereof

The present invention relates to a hybrid fluorine-based nonionic surfactant containing a short fluorinated alkyl group, and a preparing method thereof, and more particularly, to a hybrid fluorine-based nonionic surfactant having one low fluorinated alkyl group and one hydrocarbon group, and a preparing method thereof. According to the present invention, the hybrid fluorine-based nonionic surfactant realizes a low surface tension and CMC even though a short fluorinated alkyl group is included in one molecule, and has high solubility in water and excellent emulsification stability, and thus has excellent physical properties as a surfactant. In addition, the hybrid fluorine-based nonionic surfactant is less harmful to the human body and the environment compared to a conventional surfactant due to low fluorinated alkyl group, and requires low manufacturing costs and thus can be beneficially used as an eco-friendly and economical fluorine-based nonionic surfactant having competitiveness in terms of price. In particular, the hybrid fluorine-based nonionic surfactant of the present invention can be beneficially used as a surfactant replacing a conventional fluorine-based nonionic surfactant containing a long perfluorinated alkyl group such as PFOA or PFOS known to be harmful to the environment and the human body.COPYRIGHT KIPO 2018

SYNTHESIS AND UTEROSTIMULATING ACTIVITY OF DERIVATIVES OF 1-DIALKYLAMINO-3-ALKOXY-2-PROPANOL

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