1323443-73-7

Basic information

• Product Name: N-(6-cyano-3,4-dihydro-3-hydroxyspiro[2H-1-benzopyran-2,1'-cyclopentane]-4-yl)-L-phenylalanine ethyl ester
• CAS NO: 1323443-73-7
• Molecular Weight: 420.508
• Mol File: 1323443-73-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(6-cyano-3,4-dihydro-3-hydroxyspiro[2H-1-benzopyran-2,1'-cyclopentane]-4-yl)-L-phenylalanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-cyano-3,4-dihydro-3-hydroxyspiro[2H-1-benzopyran-2,1'-cyclopentane]-4-yl)-L-phenylalanine ethyl ester(1323443-73-7)
• EPA Substance Registry System: N-(6-cyano-3,4-dihydro-3-hydroxyspiro[2H-1-benzopyran-2,1'-cyclopentane]-4-yl)-L-phenylalanine ethyl ester(1323443-73-7)

Safety Data

• Hazardous Substances Data: 1323443-73-7(Hazardous Substances Data)

Upstream product

• 767-00-0 4-cyanophenol 
• 3081-24-1 H-Phe-OEt 
• 123595-62-0 C₁₄H₁₃NO₂ 
• 13031-41-9 4-cyanophenyl acetate 
• 35794-84-4 2-hydroxy-5-cyanoacetophenone 
• 126973-26-0 C₁₄H₁₃NO 
• 126973-25-9 C₁₄H₁₅NO₂ 
• 126973-24-8 C₁₄H₁₃NO₂ 

Relevant articles and documents

Design, synthesis and biological evaluation of benzopyran derivatives as KATP channel openers

In order to complete the SAR and discover new potent and selective PCOs, some changes were made to the C-4 and C-2 substitutions of cromakalim. A series of 4 -amino acid substituted -2, 2-dialkylchromans structurally related to cromakalim were synthesized and evaluated, as ATP-sensitive potassium channel openers (8a-l). Preliminary biological tests suggested that these compounds exhibited potent to mild relaxation activity of the KCl-contracted rat aortic strips. Compounds 8b (IC50 =0.25μM), 8f (IC50 =6.44μM) and 8j (IC50 =8.65μM) exhibited commendable opening activity of potassium channels. In addition to anti-hypertension, these compounds can also be considered as lead candidates for the further development of myocardial antiischemic drugs.