132370-60-6

Basic information

• Product Name: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine
• Synonyms: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine
• CAS NO: 132370-60-6
• Molecular Weight: 455.517
• Mol File: 132370-60-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine(132370-60-6)
• EPA Substance Registry System: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine(132370-60-6)

Safety Data

• Hazardous Substances Data: 132370-60-6(Hazardous Substances Data)

Upstream product

• 132370-68-4 6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine 
• 132370-64-0 6-dimethylamino-9-(2'-deoxy-β-D-xylofuranosyl)purine 
• 87-42-3 6-chloropurine 
• 132370-61-7 6-chloro-9-(2'-O-acetyl-3',5'-di-O-benzoyl-β-D-xylofuranosyl)purine 
• 132370-62-8 6-dimethylamino-9-(3',5'-di-O-benzoyl-β-D-xylofuranosyl)purine 
• 132370-63-9 6-dimethylamino-9-(2'-deoxy-3',5'-di-O-benzoyl-β-D-xylofuranosyl)purine 
• 132370-70-8 6-dimethylamino-9-(2'-deoxy-3'-O-mesyl-5'-O-pivaloyl-β-D-xylofuranosyl)purine 
• 132370-66-2 6-dimethylamino-9-(2',3'-dideoxy-3'-azido-5'-O-pivaloyl-β-D-ribofuranosyl)purine 
• 85026-60-4 (3R,4S,5R)-4-(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,3-diyl diacetate 
• 132370-65-1 6-dimethylamino-9-(2'-deoxy-5'-O-pivaloyl-β-D-xylofuranosyl)purine 
• 132370-67-3 6-dimethylamino-9-(3'-azido-2',3'-dideoxy-3'-β-D-ribofuranosyl)purine 
• 17554-34-6 (2S)-2-[(benzyloxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid 
• 132370-69-5 6-dimethylamino-9-(3',5'-di-O-benzoyl-2'-O-phenoxythiocarbonyl-β-D-xylofuranosyl)purine 

Relevant articles and documents

2'-Deoxypuromycin: Synthesis and antiviral evaluation

A new synthesis of 2'-deoxypuromycin (18) as well as its α-anomer 17 is described. Reaction of 1,5-di-O-acetyl-2,3-dideoxy-3-phthalimido-β-D-erythro-pentofuranose (3) with silylated 6-dimethylaminopurine using trimethylsilyl trifluoromethanesulfonate as catalyst afforded the α and β nucleosides 7 and 12 in 15 and 25% yield, respectively. After deblocking of both amino and hydroxy groups with methylamine in ethanol, the nucleosides were condensed with Fmoc-4-O-methyl-L-tyrosine and subsequently deprotected to give the target compounds 17 and 18. Compound 3 is converted into its glycosyl bromide 4 in quantitative yield on treatment with trimethylsilyl bromide, and reacted with the sodium salt of 6-dimethylaminopurine to give the corresponding protected N-7 and N-9 α glycosyl nucleosides 7 and 8 in 34 and 39% yield, respectively. The 2'-deoxypuromycin is inactive against HIV-1 in MT-4 cells.