1324008-91-4

Basic information

• Product Name: tert-butyl 4-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate
• CAS NO: 1324008-91-4
• Molecular Weight: 479.112
• Mol File: 1324008-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate(1324008-91-4)
• EPA Substance Registry System: tert-butyl 4-bromo-5-iodo-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate(1324008-91-4)

Safety Data

• Hazardous Substances Data: 1324008-91-4(Hazardous Substances Data)

Upstream product

• 140907-23-9 tert-butyl 3-bromoprop-2-ynoate 
• 201282-63-5 4-iodo-3-(4-methoxyphenyl)-3H-1,2,3-oxadiazol-1-ium-5-olate 
• 13831-03-3 tert-butyl prop-2-ynoate 
• 3815-80-3 3-(p-anisyl)sydnone 

Relevant articles and documents

Facile access to 3,5-dihalogenated pyrazoles by sydnone cycloaddition and their versatile functionalization by Pd-catalyzed cross-coupling processes

The 1,3-dipolar cycloaddition of diversely N-substituted 4-iodosydnones with 3-halopropiolates produces easily separable mixtures of dihalogenated pyrazolylcarboxylic esters at a preparative scale level, with the 3,5-dihalogenopyrazole regioisomers always predominating. Further decarboxylation of the major isomers provided the corresponding 3,5-dihalogenopyrazoles with a free C-4 position. These were found to be valuable scaffolds for the elaboration of unsymmetrically 1,3,5-trisubstituted pyrazole derivatives by site-selective Pd-catalyzed cross-coupling reactions. Notably, the flexible and site-selective introduction of different (hetero)aryl, vinyl, or alkyl substituents at the C-5 and C-3 positions of the pyrazole core could be achieved through sequential Suzuki-type reactions with various boron compounds. Copyright