132414-81-4

Basic information

• Product Name: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
• Synonyms: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE;Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylic acid tert-butyl ester;5-N-Boc-hexahydro-pyrrolo[3,4-b]pyrrole;Tert-butyl 2,7-diazabicyclo[3.3.0]octan-7-carboxylate;Pyrrolo[3,4-b]pyrrole-5(1H)-carboxylic acid, hexahydro-, 1,1-diMethylethyl ester;Octahydro-pyrrolo[3,4-b]pyridine-6-carboxylic acid tert-butyl ester;t-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate;tert-butyl octahydropyrrolo[3,4-b]pyrrole-5-carboxylate
• CAS NO: 132414-81-4
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.29
• Mol File: 132414-81-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.397 °C at 760 mmHg
• Flash Point: 132.451 °C
• Appearance: /
• Density: 1.076g/cm³
• Vapor Pressure: 2.13E-06mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.72±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE(132414-81-4)
• EPA Substance Registry System: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE(132414-81-4)

Safety Data

• Hazard Codes: N
• Statements: 50/53-50
• Safety Statements: 60-61
• RIDADR: UN3077
• Hazardous Substances Data: 132414-81-4(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE, also known as THP-CP, is a chemical compound with the molecular formula C15H27NO2. It is a bicyclic pyrrole derivative that contains a tert-butyl ester functional group. THP-CP has potential applications in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. It is also used in organic chemical synthesis as a versatile intermediate for the preparation of complex molecular structures. THP-CP is known for its high stability and compatibility with a wide range of reaction conditions, making it a valuable and versatile chemical compound in the field of organic chemistry.

InChI:InChI=1/C18H26N2O2/c1-18(2,3)22-17(21)20-12-15-9-10-19(16(15)13-20)11-14-7-5-4-6-8-14/h4-8,15-16H,9-13H2,1-3H3

Upstream product

• 132414-80-3 tert-butyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate 
• 132414-50-7 1-benzyl-octahydropyrrolo[2,3-c]pyrrole 
• 132414-78-9 ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate 
• 128740-03-4 N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester 
• 128740-02-3 ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 
• 34619-03-9 tert-butyldicarbonate 

Relevant articles and documents

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS

The invention relates to the phenylaminopyrimidines of formula (I), wherein A, D, R1, R2, R3 and R4 are defined as in the description. The invention also relates to methods for producing said phenylaminopyrimidines and to their use for producing drugs for the treatment and/or the prophylaxis of diseases, especially cardiovascular diseases.

Preparation of 2,7-diazabicyclo[3.3.0]octanes

2,7-Diazabicyclo[3.3.0]octanes, suitable for 7-position substituents or antibacterially active quinolone carboxylic acids, of the formula STR1 in which R1, R3, R4, R5, R7 and R8 may be identical or different and in each case denote H, C1 -C5 -alkyl (optionally substituted by halogen, hydroxyl or C1 -C3 -alkoxy), C1 -C3 -alkoxycarbonyl or C6 -C12 -aryl, R4 additionally denotes halogen, R2 and R6 may be identical or different, denote H, C1 -C6 -alkyl, benzyl, C6 -C12 -aryl, C1 -C3 -alkanoyl, benzoyl or C1 -C5 -alkoxycarbonyl, or R2 and R3 together denote a bridge of the structure (CH2)n, n=2-4, CH2 --CHOH--CH2, CH2 --S--CH2 or C(CH3)2 --S--CH2, excluding 2,7-diazabicyclo[3.3.0]octane. Also their preparation by the reaction STR2 Intermediates II are also new.