1438080-49-9

Basic information

• Product Name: tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate
• Synonyms: tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate
• CAS NO: 1438080-49-9
• Molecular Weight: 572.079
• Mol File: 1438080-49-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate(1438080-49-9)
• EPA Substance Registry System: tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3.4-b]pyrrole-5(1H)carboxylate(1438080-49-9)

Safety Data

• Hazardous Substances Data: 1438080-49-9(Hazardous Substances Data)

Upstream product

• 179688-52-9 6-hydroxy-7-methoxyquinazolin-4(3H)-one 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 13794-72-4 3H-6,7-dimethoxyquinazolin-4-one 
• 184475-71-6 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline 
• 788136-89-0 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate 
• 230955-75-6 6-acetoxy-4-chloro-7-methoxyquinazoline 
• 179688-53-0 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one 
• 912556-91-3 6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine 
• 132414-81-4 tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate 

Downstream Products

• 1438072-53-7 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydropyrrolo[3.4-b]pyrrol-1(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438072-59-3 1-(1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone 

Relevant articles and documents

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.