132439-41-9Relevant articles and documents
Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3- (substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption
Middleton, Donald S.,MacKenzie, A. Roderick,Newman, Sandra D.,Corless, Martin,Warren, Andrew,Marchington, Allan P.,Jones, Barry
, p. 3957 - 3961 (2007/10/03)
A series of piperidone analogues of 1b-q, seeking replacements for the polar sulfamide moiety in clinical candidate UK-224,671 1a, possessing reduced H-bonding potential as a strategy to improve oral absorption, were prepared. These studies led to the successful identification of 1n, which demonstrated equivalent pharmacology and metabolic stability to 1a, and greatly improved oral absorption as assessed in rat PK studies.
Photolysis of azoalkane. Reactions and kinetics of the 1-cyclopropylcyclopentane-1,3-diyl biradical and the 1-cyclopropylcyclopentyl radical
Engel, Paul S.,Culotta, Anne Marie
, p. 2686 - 2696 (2007/10/02)
The cyclopropylcarbinyl (CPC) rearrangement rates of 1-cyclopropylcyclopentyl (10a) and 1-cyclopropylcyclohexyl (10b) radicals to yield 34a,b are found to be 1.45 × 107 and 1.1 × 107 s-1 at 24.7°C, respectively. These valu
