194427-21-9

Basic information

• Product Name: N-(1-Cyclopropylcyclopent-1-yl)-4(S)-4-(3,4-dichlorophenyl)-4-methanesulphonyloxymethylhept-6-enamide
• CAS NO: 194427-21-9
• Molecular Weight: 488.475
• Mol File: 194427-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1-Cyclopropylcyclopent-1-yl)-4(S)-4-(3,4-dichlorophenyl)-4-methanesulphonyloxymethylhept-6-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-Cyclopropylcyclopent-1-yl)-4(S)-4-(3,4-dichlorophenyl)-4-methanesulphonyloxymethylhept-6-enamide(194427-21-9)
• EPA Substance Registry System: N-(1-Cyclopropylcyclopent-1-yl)-4(S)-4-(3,4-dichlorophenyl)-4-methanesulphonyloxymethylhept-6-enamide(194427-21-9)

Safety Data

• Hazardous Substances Data: 194427-21-9(Hazardous Substances Data)

Upstream product

• 120-92-3 cyclopentanone 
• 132439-40-8 1-cyclopropylcyclopentylazide 
• 132439-41-9 1-cyclopropylcyclopentylamine 
• 59819-64-6 1-cyclopropylcyclopentanol 
• 194427-20-8 N-(1-Cyclopropylcyclopent-1-yl)-4(S)-4-(3,4-dichlorophenyl)-4-hydroxymethylhept-6-enamide 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 194427-22-0 5(S)-5-Allyl-1-(1-cyclopropylcyclopent-1-yl)-5-(3,4-dichlorophenyl)piperidin-2-one 

Relevant articles and documents

Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3- (substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption

A series of piperidone analogues of 1b-q, seeking replacements for the polar sulfamide moiety in clinical candidate UK-224,671 1a, possessing reduced H-bonding potential as a strategy to improve oral absorption, were prepared. These studies led to the successful identification of 1n, which demonstrated equivalent pharmacology and metabolic stability to 1a, and greatly improved oral absorption as assessed in rat PK studies.